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孕产妇在早产期间与产生扩展谱β-乳糖酶的肠杆菌菌和垂直传播的母体殖民
Thanyaporn Suntiviriyapadung1, Chonnamet Techasaensiri, Nopporn Apiwattanakul
1From the Department of Pediatrics; and †Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital Mahidol University, Bangkok, Thailand.
The Pediatric infectious disease journal
|December 24, 2025
概括
扩展光谱β-乳糖酶产生肠杆菌菌 (ESBL-E) 的母体殖民与不良的早产婴儿结局有关. 针对性查和更广泛的抗生素使用建议在风险新生儿.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 过早出生的婴儿面临着严重的发病和死亡风险.
- 早发性新生儿败血症 (EOS) 是早产婴儿的一个关键问题.
- 抗菌素耐药性,特别是来自扩展谱β-lactamase产生的Enterobacteriaceae (ESBL-E),使新生儿败血症治疗复杂化.
研究的目的:
- 为了评估母体ESBL-E殖民的情况.
- 为了确定ESBL-E从母亲向婴儿的垂直传播率.
- 评估母体ESBL-E殖民对新生儿结局的影响.
主要方法:
- 在泰国曼谷Ramathibodi医院进行了一项前性队列研究.
- 患有早产或早产前膜破裂的孕妇进行了阴道ESBL-E殖民的查.
- 新生儿表面培养是在出生时获得的,并比较了母亲的风险因素和新生儿结果.
主要成果:
- 母亲ESBL-E殖民发生在6.4%的分娩中,垂直传播率为20%.
- 孕产妇殖民的危险因素包括宫手术和之前的B组菌株 (GBS) 殖民.
- 殖民母亲的婴儿有较早的妊娠年龄,较高的剖腹产率,较低的出生体重和更长的住院时间.
结论:
- 宫手术和之前的GBS殖民与母体ESBL-E殖民有关.
- 被殖民母亲生下的婴儿经历了较差的新生儿结果.
- 针对性查和更广泛的经验性抗生素覆盖是有风险的早产婴儿需要的.
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