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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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在体内检测到的脑微出血 (CMB) 在死后持续存在,并且在体外MRI上可见. 较高的CMB计数与认知能力下降和大脑粉样血管病变 (CAA) 相关联.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经病理学神经病理学
  • 老年学是指老年学的学科.

背景情况:

  • 大脑微出血 (CMB) 是老年人常见的小出血.
  • 脑脊髓炎与认知能力下降,大脑体积减少以及中风和死亡风险增加有关.
  • 这项研究调查了体内和体外检测到的CMB,将发现与临床和病理数据相关联.

研究的目的:

  • 为了确定体内检测到的脑微血 (CMBs) 是否可以在死后使用体外MRI识别.
  • 评估体内和体外CMB发现和临床评估之间的关系.
  • 调查CMB与神经病理学的关联,包括大脑粉样血管病变 (CAA).

主要方法:

  • 一项对37名社区老年人的纵向研究,涉及每年认知测试和脑部核磁共振.
  • 在体内MRI (3D-T1w MPRAGE,ME-GRE) 和体外MRI (3D ME-SE,ME-GRE) 获得.
  • 神经病理学评估包括脑血管病理;CMB被注释并比较体内和体外扫描.

主要成果:

  • 59%的参与者在体外MRI上至少有一个CMB.
  • 65%的体内CMB与体外CMB完全匹配.
  • 活体外CMB计数高于体内计数,特别是在具有较大的认知障碍和脑粉样血管病变 (CAA) 的个体中.

结论:

  • 在生命期间观察到的脑微血流 (CMB) 在大脑中持续存在,并可通过体外MRI检测.
  • 在经历认知障碍和脑粉样血管病变 (CAA) 的个体中,CMB的数量随着时间的推移而增加.
  • 这项研究验证了ex vivoMRI作为检测持久性CMB及其与神经退行性疾病相关性的工具.