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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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基础科学和病原发生学

Joice Coutinho de Alvarenga1,2,3,4, Ivonne Carolina Bolaños Burgos5, Gabriela Tomé Oliveira Engelmann1,4,6,7

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概括

脑脊液中eotaxin-1水平在没有认知障碍的个体中较低. 较高的eotaxin-1与轻度认知障碍 (MCI) 和痴呆症的认知衰退有关.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生化学
  • 老年学是一门学科.

背景情况:

  • 欧素-1 (CCL11) 可能抑制神经发生,并且与轻度认知障碍 (MCI) 和痴呆症中中部叶体积减少有关.
  • 了解eotaxin-1在认知衰退中的作用对于开发有针对性的干预措施至关重要.

研究的目的:

  • 研究大脑脊髓液 (CSF) 中eotaxin-1 (CCL11) 水平与巴西老年人的认知功能之间的关联.
  • 为了确定eotaxin-1是否可以作为认知障碍的生物标志物.

主要方法:

  • 从Cog-Aging队列研究 (2023-2024) 中对108名老年人的横截面研究.
  • 进行了认知评估 (CDR,MMSE) 和CSF收集.
  • 使用Luminex xMAP测量了细胞因子水平,包括eotaxin-1.
  • 统计分析包括斯皮尔曼,曼 - 惠特尼,克鲁斯卡尔 - 瓦利斯与恩的后 hoc 和后勤回归.

主要成果:

  • 乙素-1水平与CDR得分有显著的正相关性,与MMSE得分有负相关性.
  • 与MCI和痴呆症患者相比,在认知不受损 (CU) 个体中观察到较低的eotaxin-1水平.
  • 后勤回归模型表明,年龄和eotaxin-1水平是认知障碍的显著预测因素,eotaxin-1的含有提高了预测准确度.

结论:

  • 在认知不受损的个体中,CSF中eotaxin-1水平明显较低.
  • 欧素-1与轻度认知障碍 (MCI) 和痴呆症的认知障碍有关,这表明其作为生物标志物的潜力.