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Updated: Jul 18, 2026

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy
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Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy

Published on: June 21, 2013

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理性设计pH可切换的3α-氨基酸基酸盐修饰脂质,以实现高效的siRNA传递

Xueying Gu1, Yunfeng Han1, Wenfeng Liu2

  • 1State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, P. R. China.

Advanced healthcare materials
|December 24, 2025
PubMed
概括

新型pH响应性脂质通过改善内体逃生来增强RNA输送. 这些修改后的脂质纳米颗粒 (LNP) 显示出下一代治疗方法的前景,克服了细胞质输送的关键挑战.

关键词:
药物输送是药物输送的过程.细胞内体逃脱的方法基因沉默是对基因进行沉默的方法.可电离的氨基脂类氨基酸.脂质纳米颗粒是一种纳米粒子.siRNA 是一个RNA.

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相关概念视频

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...