基础科学和病原发生学
Razaq O Durodoye1, Timothy H Ciesielski1, Penelope Benchek2
1Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
种族和种族捕捉了晚发性阿尔茨海默病 (LOAD) 的非遗传风险因素. 这些因素,包括非医疗健康驱动因素,独立地与LOAD风险相关,超出了遗传贡献.
科学领域:
- 遗传学和基因组学 在
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 种族和种族 (R/E) 经常被用来分层参与者在晚发性阿尔茨海默病 (LOAD) 的遗传研究.
- R/E类别有助于识别风险等位基因,量化效果大小变化,并评估跨群体的病因差异.
- R/E可以作为未测量的外部风险因素的代理,例如种族/种族和非医疗健康驱动因素 (NMDH) 的生活经验.
研究的目的:
- 估计R/E对LOAD风险的非遗传贡献.
- 调整遗传风险因素和祖先,同时评估R/E的影响.
主要方法:
- 利用来自42,015名阿尔茨海默氏病遗传联盟 (ADGC) 参与者的遗传和人口数据,跨越多种R / E组.
- 进行了后勤回归,调整了APOE基因型,年龄,性别和遗传血统,以确定R/E捕获的NMDH贡献.
- 采用K-means集群来识别基因上不同的群体,并使用这些集群重新评估回归模型.
主要成果:
- 与非西班牙裔黑人 (NHB) 个人相比,东亚 (EAS),非西班牙裔白人 (NHW) 和西班牙裔/拉丁裔 (HIS) 参与者显示LOAD的几率明显增加 (OR分别为2.43和2.07和2.04).
- 通过K-means集群识别了五种遗传祖先:非洲人,东亚人,欧洲人,美洲印第安人和遗传混合的拉丁人.
- 即使调整了遗传因素后,R/E仍然是LOAD风险的重要预测因素,这表明它捕捉了超越遗传的风险.
结论:
- 外在因素,特别是通过R / E捕获的NMDH,与LOAD风险独立相关.
- 这项研究强调了在阿尔茨海默病研究中考虑社会环境因素的重要性.
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