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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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基础科学和病原发生学

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概括
此摘要是机器生成的。

种族和种族捕捉了晚发性阿尔茨海默病 (LOAD) 的非遗传风险因素. 这些因素,包括非医疗健康驱动因素,独立地与LOAD风险相关,超出了遗传贡献.

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科学领域:

  • 遗传学和基因组学 在
  • 神经科学是一个神经科学.
  • 公共卫生 公共卫生

背景情况:

  • 种族和种族 (R/E) 经常被用来分层参与者在晚发性阿尔茨海默病 (LOAD) 的遗传研究.
  • R/E类别有助于识别风险等位基因,量化效果大小变化,并评估跨群体的病因差异.
  • R/E可以作为未测量的外部风险因素的代理,例如种族/种族和非医疗健康驱动因素 (NMDH) 的生活经验.

研究的目的:

  • 估计R/E对LOAD风险的非遗传贡献.
  • 调整遗传风险因素和祖先,同时评估R/E的影响.

主要方法:

  • 利用来自42,015名阿尔茨海默氏病遗传联盟 (ADGC) 参与者的遗传和人口数据,跨越多种R / E组.
  • 进行了后勤回归,调整了APOE基因型,年龄,性别和遗传血统,以确定R/E捕获的NMDH贡献.
  • 采用K-means集群来识别基因上不同的群体,并使用这些集群重新评估回归模型.

主要成果:

  • 与非西班牙裔黑人 (NHB) 个人相比,东亚 (EAS),非西班牙裔白人 (NHW) 和西班牙裔/拉丁裔 (HIS) 参与者显示LOAD的几率明显增加 (OR分别为2.43和2.07和2.04).
  • 通过K-means集群识别了五种遗传祖先:非洲人,东亚人,欧洲人,美洲印第安人和遗传混合的拉丁人.
  • 即使调整了遗传因素后,R/E仍然是LOAD风险的重要预测因素,这表明它捕捉了超越遗传的风险.

结论:

  • 外在因素,特别是通过R / E捕获的NMDH,与LOAD风险独立相关.
  • 这项研究强调了在阿尔茨海默病研究中考虑社会环境因素的重要性.