Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Reverse-engineering amyloid strains with generative protein design.

bioRxiv : the preprint server for biology·2026
Same author

RadTranslateGPT: An Improved AI-Based System for Translation and Simplification of Structured Radiology Reports.

Journal of the American College of Radiology : JACR·2026
Same author

Deciphering Environmental Health Factors Behind Unknown Etiology of Chronic Kidney Disease in South Asia: Plans for Epidemiologic Study.

medRxiv : the preprint server for health sciences·2026
Same author

Preparing for Pandemics with Large Language Models: An Evaluation of Sensitivity Across COVID-19, Zika, and Monkeypox Case Reports.

Journal of medical systems·2026
Same author

HDAC6 as a Modulator of DNA Repair in Alzheimer's Disease: From Mechanisms to Therapeutic Perspectives.

ACS chemical neuroscience·2025
Same author

Designing Patient-Centered Communication Aids in Pediatric Surgery Using Large Language Models.

Journal of pediatric surgery·2025

相关实验视频

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Aneesh Mazumder1, Anirudh Mazumder2, Claire Suen1

  • 1Harvard College, Cambridge, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

像GPT-4o这样的大型语言模型 (LLM) 可以从有关阿尔茨海默病 (AD) 和基因素脱乙酶6 (HDAC6) 的科学文献中构建知识图 (KGs). GPT-4o在提取AD研究的分子相互作用方面表现出更高的准确性.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 计算生物学 计算生物学
  • 生物化学 生物化学

背景情况:

  • 阿尔茨海默病 (AD) 涉及复杂的分子途径超出了经典病理,包括基因素脱乙酶6 (HDAC6).
  • 越来越多的科学文献需要先进的知识提取方法和AD的途径分析.
  • 大型语言模型 (LLM) 提供了一个强大的解决方案,可以在广泛的生物医学文本中总结和发现知识.

研究的目的:

  • 开发和评估基于LLM的方法,用于构建阿尔茨海默病 (AD) 中分子相互作用的知识图 (KGs).
  • 在AD.中系统地绘制涉及基因素脱乙酶6 (HDAC6) 的复杂分子通路.
  • 为了比较不同LLM在从科学摘要中提取结构化信息方面的表现.

主要方法:

  • 使用GPT-4o和Gemini处理了265个关于AD和HDAC的PubMed摘要集.
  • 通过LLM提取了主体-预言-对象三重体,标准化了分子实体 (通过UniProt) 和动词类别.
  • 提取的三胞胎被汇总成一个知识图 (KG),通过人类准确性评估来评估性能.

主要成果:

  • 构建了一个知识图,识别了关键的分子节点,如Tau,化合物15和HDAC6.
  • 与Gemini的58.9%相比,GPT-4o在提取分子相互作用方面获得了78.4%的更高准确度.
  • 该KG提供了已知分子相互作用的结构化概述和AD的潜在研究缺口.

结论:

  • 法律学,特别是GPT-4o,可以有效地从AD和HDAC研究中提取结构化知识,促进系统的理解.
  • 开发的KG方法作为识别AD新型治疗点的基础.
  • 这种方法显示了在各种研究领域自动化科学发现的巨大潜力.