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相关概念视频

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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基础科学和病原发生学

Yannick Joel Wadop Ngouongo1, Bernard Fongang2,3,4, Stephen Z Levine5

  • 1Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

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此摘要是机器生成的。

注意缺陷多动症 (ADHD) 的更高遗传风险与成人痴呆风险增加有关. 吸烟显著调解了这种关联,突出了生活方式因素在痴呆症预防中的重要性.

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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 公共卫生 公共卫生

背景情况:

  • 注意缺陷多动症 (ADHD) 与不良健康行为和痴呆风险增加有关.
  • 由于诊断不足,ADHD诊断经常被错误分类,特别是在成年人中.
  • 对ADHD的遗传倾向可以提供对痴呆症风险的见解,绕过诊断限制.

研究的目的:

  • 调查ADHD多基因风险评分 (PRS) 和发病性痴呆症之间的关联.
  • 探索生活方式因素和健康感知在ADHD-痴呆症关系中的调解作用.

主要方法:

  • 利用英国生物库数据,从GWAS总结统计数据计算ADHD PRS.
  • 确定的痴呆症 (所有原因,血管痴呆症 (VaD),阿尔茨海默病 (AD)) 使用ICD代码.
  • 使用多变量回归和调解分析来评估关联和间接影响.

主要成果:

  • 较高的ADHD PRS与所有原因痴呆症,VaD和AD的风险增加显著相关.
  • ADHD PRS与吸烟,咖啡消费,体力活动,酒精使用以及较差的健康感知有关.
  • 吸烟调解了ADHD PRS和全因痴呆症 (7%) 和VaD (9.2%) 之间的关系.

结论:

  • 对ADHD的遗传倾向与中年和老年人痴呆症风险有显著联系.
  • 吸烟在ADHD遗传风险和痴呆症之间的关联中起着重要的调解作用.
  • 解决可修改的生活方式因素,如戒烟,对于减轻基因易感个体痴呆风险至关重要.