基础科学和病原发生学
Yannick Joel Wadop Ngouongo1, Bernard Fongang2,3,4, Stephen Z Levine5
1Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
注意缺陷多动症 (ADHD) 的更高遗传风险与成人痴呆风险增加有关. 吸烟显著调解了这种关联,突出了生活方式因素在痴呆症预防中的重要性.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 注意缺陷多动症 (ADHD) 与不良健康行为和痴呆风险增加有关.
- 由于诊断不足,ADHD诊断经常被错误分类,特别是在成年人中.
- 对ADHD的遗传倾向可以提供对痴呆症风险的见解,绕过诊断限制.
研究的目的:
- 调查ADHD多基因风险评分 (PRS) 和发病性痴呆症之间的关联.
- 探索生活方式因素和健康感知在ADHD-痴呆症关系中的调解作用.
主要方法:
- 利用英国生物库数据,从GWAS总结统计数据计算ADHD PRS.
- 确定的痴呆症 (所有原因,血管痴呆症 (VaD),阿尔茨海默病 (AD)) 使用ICD代码.
- 使用多变量回归和调解分析来评估关联和间接影响.
主要成果:
- 较高的ADHD PRS与所有原因痴呆症,VaD和AD的风险增加显著相关.
- ADHD PRS与吸烟,咖啡消费,体力活动,酒精使用以及较差的健康感知有关.
- 吸烟调解了ADHD PRS和全因痴呆症 (7%) 和VaD (9.2%) 之间的关系.
结论:
- 对ADHD的遗传倾向与中年和老年人痴呆症风险有显著联系.
- 吸烟在ADHD遗传风险和痴呆症之间的关联中起着重要的调解作用.
- 解决可修改的生活方式因素,如戒烟,对于减轻基因易感个体痴呆风险至关重要.
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