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神经免疫十字路口:双极性障碍和炎症性肠道疾病之间的病理生理联系
Giuseppe Marano1, Francesca Bardi1, Emanuela De Chiara1
1Unit of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy; Department of Neurosciences, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Actas espanolas de psiquiatria
|December 24, 2025
概括
双极性障碍 (BD) 和炎症性肠病 (IBD) 经常同时发生,影响患者的健康和治疗. 共享的炎症通路和肠-大脑轴将这些疾病联系在一起,需要综合护理.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 双极性障碍 (BD) 和炎症性肠病 (IBD) 经常同时发生,带来复杂的治疗挑战.
- 有关的共享炎症机制,但BD和IBD之间的临床和病理生理相互作用是不太了解的.
研究的目的:
- 审查有关双相情感障碍和炎症性肠道疾病的并发症现有文献.
- 描述BD-IBD重叠的临床,流行病学和机制方面的特征.
主要方法:
- 对2000年1月至2025年5月的同行评审文献进行了叙述性审查.
- 在PubMed,Web of Science和PsycINFO进行了搜索,使用与BD,IBD,并发症和炎症标志物相关的术语.
- 在查后,报告了BD-IBD重叠的临床,流行病学或机理学数据的研究被纳入.
主要成果:
- BD影响IBD患者的3-7%,明显高于一般人群 (1-2%).
- 并发性BD-IBD与住院病例增加,严重的胃肠道和精神症状以及生活质量的降低有关.
- 存在复杂的治疗相互作用,精神病药物可能加剧炎症,IBD治疗可能使情绪不稳定. 失调的细胞因子,肠道微生物组的改变和遗传因素是涉及的机制性途径.
结论:
- BD和IBD的同时出现突出了由系统性炎症调解的双向肠-大脑神经免疫轴.
- 综合,多学科的护理对于管理这种并发症至关重要.
- 未来的研究应该优先考虑纵向研究和有针对性的抗炎干预措施,以改善患者的治疗结果.
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