酒精使用障碍和发生COVID-19感染的风险:台湾的一项嵌套病例控制研究
Yung-Feng Yen1,2,3,4,5, Yun-Ju Lai3,6,7,8, Sheng-Siang Su9
1Section of Infectious Diseases, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan.
Addiction (Abingdon, England)
|December 24, 2025
概括
患有酒精使用障碍 (AUD) 的人患COVID-19感染的风险更高. 为预防COVID-19优先考虑AUD患者至关重要.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 酒精使用障碍 (AUD) 可能通过上调血管酶转化酶2 (ACE2) 来增加对严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 的易感性.
- 在AUD和2019年冠状病毒疾病 (COVID-19) 发病率之间确切的关联仍然不完全理解.
研究的目的:
- 为了调查酒精使用障碍 (AUD) 和患COVID-19感染的风险之间的关联.
- 为了确定AUD是否是COVID-19发病率的独立风险因素.
主要方法:
- 一项使用台湾国家健康保险研究数据库的队列研究.
- 包括247,000名有AUD的个人和2,470,000名没有AUD的匹配对照,追踪到2021年12月31日.
- 考克斯回归模型被用来评估AUD对COVID-19感染风险的影响,并考虑了竞争风险.
主要成果:
- 该研究在2,717,000名参与者中确定了2,374起COVID-19事件病例.
- 在对共变量进行调整后,患有AUD的个体在统计学上显著地显示出更高的COVID-19感染风险 (调整后的危险比:1.19;95%CI:1.06-1.34)
- 在大多数子组中,AUD与COVID-19风险增加有关,但在年轻人 (18-49岁),男性和未接种疫苗的人中例外.
结论:
- 酒精使用障碍 (AUD) 是发生COVID-19感染的独立风险因素.
- 患有AUD的个人代表了针对性COVID-19预防策略的关键人群.
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