相关实验视频

Updated: Aug 12, 2026

Profiling Individual Human Embryonic Stem Cells by Quantitative RT-PCR
09:03

Profiling Individual Human Embryonic Stem Cells by Quantitative RT-PCR

Published on: May 29, 2014

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单细胞转录组元分析揭示了1q21.1 CNVs来自人类ESCs的发育神经元中的表观基因组和染色质失调

Kosuke Torigata1, Jun Nomura1, Toru Takumi1

  • 1Department of Physiology and Cell Biology, Kobe University School of Medicine, Kobe, Japan.

Autism research : official journal of the International Society for Autism Research
|December 24, 2025
PubMed
概括

这项研究分析了1q21.1复制数变异 (CNV) 的人类模型中的单细胞转录组,揭示了自闭症谱系障碍 (ASD) 和精神分裂症相关的基因网络. 代体PHD指转录因子 (BPTF) 成为这些神经发育障碍中的关键表观遗传调节者.

关键词:
在这种情况下,染色染色素副本编号变化 副本编号变化显基因组是一个表观基因组.人类ES细胞单细胞转录组是一个单细胞转录组.

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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

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相关概念视频

Meiosis I01:49

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
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Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...