在耐火性心痛中对脊髓刺激的前性评估:来自单中心队列的见解
Nigar Z Gasimova1, Artem A Paltsev1, Nikita A Zayachkovskiy1
1Almazov National Medical Research Center, Saint-Petersburg, Russia.
Frontiers in cardiovascular medicine
|December 24, 2025
概括
脊髓刺激 (SCS) 没有改善耐性心痛患者的生活质量,但改善了疼痛和心理健康. 住院率显著下降,尽管并发症率显著.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 耐火性胸痛 presents一个显著的临床挑战与持续的胸痛.
- 目前的治疗方法包括最大限度的医疗疗法和重血管化,往往取得有限的成功.
- 脊髓刺激 (SCS) 作为一种新的治疗选择正在被探索.
研究的目的:
- 为了评估侵袭性脊髓刺激 (SCS) 在耐火性心痛患者的疗效和安全性.
- 评估SCS对疾病特异性生活质量和一般健康的影响.
- 为了确定不良事件的发生率和药物使用中的变化.
主要方法:
- 21名耐火性心痛患者接受了SCS植入.
- 患者接受了慢性连续和按需刺激方案.
- 主要终点:西雅图心痛问卷 (SAQ-19) 评分;次要终点:SF-36评分,心血管事件,并发症,酸盐使用.
主要成果:
- 没有观察到SAQ-19得分的显著改善.
- SF-36得分显示疼痛,心理健康和身体功能有所改善.
- 住院率显著下降 (每名患者/年3.8至0.5).
- 并发症包括设备提取 (14%) 和重新定位 (19%).
结论:
- 脊髓刺激 (SCS) 没有满足耐火性心痛中生活质量的主要终点.
- SCS显示了其次要益处,改善了身体功能,疼痛和心理健康.
- 观察到住院病例的显著减少,但并发症率需要考虑.
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