克洛托在糖尿病中:研究进展和临床影响
Tingyuan Zhu1, Songfeng Zhao2, Ning Lu1
1Department of Clinical Laboratory, The First People's Hospital of Xiaoshan District, Hangzhou, China.
Frontiers in endocrinology
|December 24, 2025
概括
克洛托是一种抗衰老蛋白,在了解和管理糖尿病及其并发症方面表现有前途. 研究强调其在葡萄糖代谢,氧化应激中的作用,以及其作为生物标志物和精确糖尿病护理的治疗点的潜力.
科学领域:
- 内分泌学和新陈代谢学
- 老年学和衰老研究研究.
- 腎病學和心血管科學.
背景情况:
- 糖尿病 (DM) 是一个重大的全球健康挑战.
- 目前的生物标志物,如HbA1c和微专尿,在早期诊断和个性化治疗方面存在局限性.
- 克洛托是一种抗衰老蛋白,因其在代谢调节和疾病发病过程中的作用而越来越受认可.
研究的目的:
- 审查Klotho的生物功能及其在糖尿病病变 (DM) 发病过程中的参与.
- 总结Klotho在糖尿病并发症中的作用,包括脏病,视网膜病变,神经病变和心血管疾病.
- 探索Klotho作为精确糖尿病管理的生物标志物和治疗点的潜力.
主要方法:
- 关于Klotho的生物功能及其与DM相关性的综合文献综述.
- 对Klotho在葡萄糖代谢和氧化应激中的调节机制的分析.
- 关于克洛托基因多态性和易患DM及其并发症的证据的审查.
主要成果:
- 克洛托在调节葡萄糖代谢和氧化应激方面发挥着重要作用,这是DM的关键因素.
- 克洛托与糖尿病主要并发症的发病有关:糖尿病病,视网膜病变,神经病变和心血管疾病.
- 克洛托基因多态可能会影响个体对DM的易感性及其相关并发症在不同人群中.
结论:
- 克洛托作为一种新的生物标志物和糖尿病治疗点具有相当大的潜力.
- 需要进一步的研究来解决循环Klotho水平的不一致性,标准化检测方法,并进行大规模的临床试验.
- 在糖尿病管理中推进精准医学需要标准化,机械学研究和Klotho研究的翻译应用.
相关概念视频
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Diabetes Mellitus: Type 2 and Gestational
4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Diabetes: Management and Pharmacotherapy
844
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
844
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Psychoneuroimmunology: Diabetes and Cancer
404
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
404


