乙球菌A菌预测ACLF,而乙球菌B菌预测了不补偿性肝硬化时的细菌感染
Lore Van Espen1, Maximilian Joseph Brol2, Lila Close1
1KU Leuven, Department of Microbiology, Immunology, & Transplantation, Rega Institute, Division of Clinical & Epidemiological Virology, Laboratory of Viral Metagenomics, Belgium.
JHEP reports : innovation in hepatology
|December 24, 2025
概括
肠道病毒组在肝硬化中发生变化,特定的菌体预测急性至慢性肝衰竭 (ACLF) 和细菌感染. 这些菌体变化与晚期肝病患者的死亡风险增加有关.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 病毒学 病毒学
背景情况:
- 肝硬化中的门性高血压损害了肠道屏障的完整性,导致细菌转移,内毒性病和全身炎症.
- 肠道菌体显著影响细菌与宿主之间的相互作用,在肝病并发症的进展中起着至关重要的作用.
- 人体肠道病毒在脱补偿性肝硬化和急性至慢性肝衰竭 (ACLF) 中的作用仍未得到充分研究.
研究的目的:
- 调查人类肠道病毒在肝硬化和ACLF急性减补的背景下的作用.
- 确定与ACLF发育和细菌感染相关的特定菌体群.
- 为了评估肠道菌体变化的预后价值在患有不补偿性肝硬化患者.
主要方法:
- 在两个独立的患者队列 (n=187) 中使用元基因组测序对便病毒组的纵向评估.
- 分析包括描述性表征,菌体宿主预测,生活方式分类和与临床参数的关联.
- 患者包括急性失补偿或ACLF患者,以及接受TIPS手术的失补偿性肝硬化患者.
主要成果:
- 菌体α多样性在ACLF患者中升高,与疾病严重程度相关.
- 在ACLF中观察到从毒性向温和菌体的转变.
- 乳球菌A菌预测了ACLF的发展 (OR=14),而Enterococcus B菌及其宿主与细菌感染有关 (OR=14.7).
- 这两种菌体家族都与90天死亡率的增加有关.
结论:
- ACLF的特点是肠道病毒组多样性的增加和向温带菌体的转变.
- 乳球球菌A与ACLF的发展有关,而Enterococcus B与细菌感染有关.
- 肠道病毒组分析有可能在临床实践中用于肝病管理的患者分层.
相关概念视频
Lysogenic Cycle of Bacteriophages
67.2K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
67.2K
Lytic Cycle of Bacteriophages
77.3K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
77.3K
Bacterial Phylum Proteobacteria
727
Proteobacteria, one of the largest and most diverse bacterial phyla, encompasses a wide range of Gram-negative bacteria distinguished by their outer membrane composed of lipopolysaccharides. These microorganisms exhibit various metabolic capabilities, including phototrophy, chemolithotrophy, and heterotrophy, and thrive in diverse environments from soil to aquatic systems and host-associated niches. The phylum is divided into six classes: Alphaproteobacteria, Betaproteobacteria,...
727
Viral Replication: Lysogenic Cycle
1.2K
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
1.2K


