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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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相关实验视频

Updated: Jan 8, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

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在治疗研究中,中国肺癌演变和微环境跟踪协议.

Wenxiang Wang1,2,3, Yue He1,2,3, Xiaoqiu Yuan3

  • 1Thoracic Oncology Institute, Peking University People's Hospital, Beijing, China.

Journal of translational internal medicine
|December 24, 2025
PubMed
概括

中国肺癌进化和治疗中的微环境跟踪 (CLEVER) 研究调查了肺癌异质性. 这项研究旨在解码分子进化和个性化治疗,以获得更好的患者结果.

关键词:
癌症的演化 癌症的演化肺癌是一种肺癌.瘤异质性的异质性

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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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科学领域:

  • 在瘤学瘤学.
  • 基因组学就是基因组学.
  • 癌症 演化 演化 癌症 演化

背景情况:

  • 通过分析单个区域,肺癌研究往往忽视了瘤异质性.
  • 现有的研究,如TRACERx,专注于西方人群,在了解亚洲肺癌方面留下了空白.
  • 瘤进化和微环境相互作用在中国肺癌中至关重要,但尚未得到充分研究.

研究的目的:

  • 通过多区域瘤采样,破译中国肺癌的分子演变.
  • 分析瘤进化和新辅助治疗对瘤微环境的影响.
  • 在中国肺癌患者中确定治疗有效性和复发的生物标志物.

主要方法:

  • 建立了未来的中国肺癌进化和微环境跟踪治疗 (CLEVER) 研究队列.
  • 从多个瘤区域获得了全面的遗传变异数据和克隆事件.
  • 使用个性化最小残留疾病 (MRD) 面板来监测突变和追踪进化意义.

主要成果:

  • 从多个地区的中国肺癌样本中获得的综合遗传变异和克隆数据.
  • 瘤微环境因进化和新辅助疗法而重塑的特征.
  • 识别影响治疗反应和复发的潜在标志物.

结论:

  • 这项CLEVER研究提供了关于中国肺癌分子演变的见解.
  • 了解瘤异质性和微环境是改善治疗策略的关键.
  • 个性化最小残留疾病监测工具有助于治疗决策和患者结果.