对于患有严重沙发静脉瘤的患者的除疗法:一个随机的,并行控制的,多中心的,非劣势性试验
Kangkang Zhi1, Sili Zou1, Yi Hong2
1Vascular Surgery Department, Changzheng Hospital, Naval Medical University, Shanghai, China.
Journal of translational internal medicine
|December 24, 2025
概括
静脉缩的粘合剂切除 (GA) 在3个月后显示不低于射频切除 (RFA),在12个月后更高的闭合率. 然而,GA程序较长,需要进一步的试验.
科学领域:
- 血管外科 血管外科
- 最少侵入性手术的方法
- 医疗器械技术 医疗器械技术
背景情况:
- 静脉静脉治疗已经转向了不那么侵袭的方法.
- 有限的长期数据存在于烯酸粘剂切除 (GA).
- 这项研究评估了GA的长期安全性和有效性.
研究的目的:
- 评估GA与射频剥离 (RFA) 相比的非劣质性.
- 评估GA对静脉的长期结果,包括安全性和有效性.
主要方法:
- 多中心,潜在的注册表比较GA (实验) 和RFA (控制).
- 177名患者的随机分配.
- 随访7天,30天,3个月,6个月和12个月,评估大沙静脉 (GSV) 闭塞,疼痛和临床分数.
主要成果:
- 在3个月的完全GSV关闭 (绝对差异-0.03%) 时,GA不低于RFA.
- 12个月GSV关闭率高于GA (绝对差异7.04%).
- GA组的手术持续时间较长 (P=0.031),但没有与设备相关的并发症;RFA使用瘤液,GA没有.
结论:
- 在3个月后,粘合剂切除 (GA) 证明与射频切除 (RFA) 对静脉缩治疗的不劣.
- 在12个月内,GA显示了更高的GSV关闭率,但需要更长的程序时间.
- 需要进一步的大规模,长期的临床试验来验证GA的疗效.
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