在早产婴儿中肠道微生物群的组成,有或没有死角性肠球炎:一个系统的审查和叙事合成
Fatemah Sadeghpour Heravi1,2,3, Gerald L Murray1,2,3, Jennifer A Danielewski1,2,3
1Department of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Parkville, Australia.
Access microbiology
|December 24, 2025
概括
在早产婴儿中死性肠球炎 (NEC) 与肠道微生物群的变化有关. 在患有NEC的婴儿中经常检测到像Enterobacteriaceae和Clostridium这样的特定细菌,这表明它们在疾病发展中的作用.
科学领域:
- 新生儿医学 新生儿医学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 结核性肠球炎 (NEC) 是一种严重的胃肠道疾病,影响早产婴儿,其特点是高死亡率.
- 肠道微生物群失生症越来越被认为是NEC病因的一个重要因素.
- 了解NEC中的特定微生物变化对于开发有针对性的干预措施至关重要.
研究的目的:
- 系统地审查和描述与没有NEC的早产婴儿之间的肠道微生物组成的差异.
- 确定与早产婴儿NEC发展相关的特定细菌种群.
- 综合当前关于肠道微生物群在NEC病变发生中的作用的证据.
主要方法:
- 从创建到2022年6月22日,对数据库进行系统的文献搜索.
- 包括使用测序方法分析有或没有NEC的早产婴儿的肠道微生物群的研究.
- 符合条件的研究结果的叙述性描述.
主要成果:
- 审查中包括了28项研究.
- 关于NEC肠道微生物群组成的发现是异质的,没有发现任何单一的普遍签名.
- NEC与增加的Enterobacteriaceae (11项研究),Clostridium (8项研究) 和Proteobacteria (2项研究) 的检测/丰度有关.
- 三项研究报告说,NEC和健康婴儿之间的肠道微生物群没有显著差异.
结论:
- 虽然发现是异质的,但特定的细菌群体,如Enterobacteriaceae,Clostridium和Proteobacteria经常与早产婴儿的NEC有关.
- 这些已识别的种群需要进一步调查它们在NEC病原发生过程中的潜在作用.
- 需要进一步的研究来阐明肠道微生物群和NEC发展之间的复杂相互作用.
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