在接受新辅助化疗的前列腺癌患者中量化部分病理反应率,使用一种新的形态测量方法进行了新辅助化疗
Wei Huang1, Huihua Li1, Philipos Tsourkas2
1Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Journal of pathology informatics
|December 24, 2025
概括
这项研究引入了一种新方法,用于评估新辅助化疗 (NAT) 后前列腺癌患者的部分病理反应率 (ppRR). 这种新的方法,使用表皮与树皮比率 (E/S),准确预测治疗疗效,并改善患者的预测结果.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 医疗成像医学成像
背景情况:
- 对新辅助化疗 (NAT) 的部分病理反应率 (ppRR) 的准确评估对于管理前列腺癌 (PCa) 至关重要.
- 之前试图在PCa中评估ppRR的尝试因估计基线癌症负担的挑战而受到限制.
- 需要一种新的形态测量方法来可靠地评估ppRR及其与患者结果的相关性.
研究的目的:
- 提出和验证一种新的形态测量方法,用于评估高风险前列腺癌患者接受NAT的ppRR.
- 在这些患者中,将计算的ppRR与无进展生存 (PFS) 相关联.
- 为了确定表皮与树皮比率 (E/S) 作为ppRR评估的替代指标的实用性.
主要方法:
- 分析了39名先前未服用NAT的高风险PCa患者的对照队列和26名接受过NAT治疗的高风险PCa患者的研究队列.
- 前列腺癌上皮质与侧膜比率 (PCa E/S) 被用作预测代孕产妇基线癌症负担 (BCB) 的指标.
- 使用PCa E/S指标计算ppRR,并进行与PFS的相关性分析,使用ppRR>80%作为切断点.
主要成果:
- 在研究队列中的26名患者中,有9名患者 (34.6%) 根据PCa E/S方法对NAT显示出显著的反应 (ppRR>80%).
- 具有显著反应的患者 (ppRR>80%) 显示出明显更好的无进展生存率 (p=0.006).
- 基于PCa E/S的方法被证明是可靠的,用于从活检和急性前列腺切除样本评估ppRR.
结论:
- 前列腺癌中对新辅助化疗 (NAT) 的部分病理反应率 (ppRR) 可靠地使用上皮细胞与树皮细胞的比率 (E/S) 作为替代指标进行评估.
- 这种使用PCa E/S从活检和急性前列腺切除样本的新型形态测量方法可以预测患者的结果,特别是无进展的生存率.
- 这些发现支持通过PCa E/S进行ppRR评估的临床实用性,以优化前列腺癌治疗策略.
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