CBMR:基于坐标的元回归用于组和共变量推理
Yifan Yu1, Lauren D Hill-Bowen2, Michael Cody Riedel3
1Oxford Big Data Institute, University of Oxford, Oxford, United Kingdom.
Imaging neuroscience (Cambridge, Mass.)
|December 24, 2025
概括
这项研究引入了一种新的基于多组坐标的元回归框架,用于神经成像. 该方法可以在不同研究组中对大脑激活模式进行可靠的比较,而不需要均衡的样本大小.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 统计分析 统计分析
背景情况:
- 基于坐标的元分析 (CBMA) 识别了跨研究的大脑激活模式.
- 在CBMA研究小组之间比较激活焦点分布是具有挑战性的,通常需要均衡的样本大小.
研究的目的:
- 引入一个灵活的多组基于坐标的元回归 (CBMR) 框架.
- 为了能够在多个神经成像研究小组中对大脑激活模式进行可靠的比较,无论样本大小如何.
主要方法:
- 为CBMR开发了一个基于spline的生成空间模型.
- 增加了粗度处罚,以灵活控制模型的光滑度.
- 通过模拟和真实的神经成像数据评估了框架.
主要成果:
- 参数推理对于至少有200个焦点的群体是有效的.
- 稀疏数据集需要通过参数引导来推断准确的结果.
- 在多组分析中,CBMR框架展示了灵活性和有效性.
结论:
- 新的CBMR框架克服了传统CBMA在多组比较方面的局限性.
- 该方法作为NiMARE模块免费提供,以促进其在功能性MRI元分析中的使用.
- 允许灵活的元回归和推断用于各种基于坐标的元分析数据集.
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