尽管药物治疗模式发生了变化,但喘控制没有改善 - - 17年随访
Caroline Ahlroth Pind1,2, Björn Ställberg3, Karin Lisspers3
1Centre for Clinical Research Västmanland, Uppsala University, Västerås, Sweden.
Journal of asthma and allergy
|December 24, 2025
概括
对于许多成年人来说,喘控制仍然不理想,在17年内几乎没有变化. 吸入性皮质类固醇的使用减少,书面行动计划变得不那么常见,增加了喘患者的风险.
科学领域:
- 肺部医学 肺部医学
- 临床研究 临床研究
- 纵向研究 纵向研究
背景情况:
- 喘控制通常报告为低,主要基于横截面数据.
- 在长时间内跟踪喘患者的纵向研究很少.
- 这项研究调查了17年的喘控制和治疗趋势.
研究的目的:
- 在成年喘患者的队列中评估长期喘控制.
- 为了评估17年来喘治疗模式的变化.
- 确定与喘控制和治疗坚持相关的因素.
主要方法:
- 一组437名成年患者 (18-75岁) 患有医生诊断的喘,被跟踪了17年.
- 参与者在2005年,2012年和2022年填写了有关症状和药物使用的问卷.
- 最佳的喘控制被定义为没有症状,有限的短期β-agonist使用,没有最近的恶化.
主要成果:
- 在整个研究期间,最佳喘控制率保持稳定,在40-42%左右.
- 定期使用吸入性皮质类固醇 (ICS) 与长效β-激动剂增加,它们作为缓解药物的使用也增加了.
- 整体上,ICS的使用和书面喘行动计划的流行率在17年内显著下降.
结论:
- 在诊断后很长时间内,低于最佳的喘控制是持续存在的问题.
- 虽然一些ICS停药可能反映了控制良好的喘,但缺乏书面行动计划会增加不适当停止治疗的风险.
- 坚持遵守喘行动计划和适当的药物使用对于长期的疾病管理至关重要.
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