在出生时,胚胎和鼻子上皮之间的基因表达模式的保存
David G Hancock1,2,3, S Patricia Agudelo-Romero1,4,5, Elizabeth Kicic-Starcevich1
1Wal-yan Respiratory Research Centre, The Kids Research Institute Australia, Nedlands, Australia.
ERJ open research
|December 24, 2025
概括
羊膜上皮的基因表达密切反映新生儿鼻上皮,表明羊膜可以作为呼吸研究的非侵入性替代组织. 这一发现支持了子宫内暴露和儿童呼吸道疾病的潜在生物标志物.
科学领域:
- 基因组学就是基因组学.
- 干细胞生物学 干细胞生物学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 胚胎上皮细胞是具有分化潜力的胎儿干细胞.
- 胚胎表皮的转录形状可能反映出新生儿呼吸表皮的特征.
研究的目的:
- 为了比较胚胎和新生儿鼻上皮之间的基因表达和网络结构.
- 评估羊水表皮作为呼吸研究的替代组织.
主要方法:
- 进行了基因表达概况和加权基因联合表达网络分析.
- 分析了85名参与者的胎和新生儿鼻上皮样本.
主要成果:
- 在胚胎和鼻子上皮之间发现了共同表达的基因的显著重叠 (79.7%).
- 共识网络分析确定了10个具有强大的结构重叠的共同表达模块.
- 共同模块中的基因被丰富为与呼吸道功能相关的途径.
结论:
- 胚胎上皮表现出显著的基因表达和网络重叠与鼻子上皮,验证它作为一个非侵入性的替代品.
- 需要进一步的研究,以探索产前呼吸道暴露和儿科疾病结果的氨基基生物标志物.
更多相关视频
08:26Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
Published on: August 31, 2016
8.3K
09:34Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
Published on: November 27, 2017
9.7K
相关概念视频
Genomic Imprinting and Inheritance
36.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.7K
Cell Specific Gene Expression
16.2K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.2K
Inheritance of Chromatin Structures
7.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.2K
Position-effect Variegation
7.0K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.0K
