在非结核性菌根性肺病患者中优化非药物干预:系统性审查
Naif Sulaiman1,2, Beatriz Martins3,2, Diana Moreira-Sousa4,2
1UCL Respiratory, University College London, London, UK.
非药物干预措施,如气道清除技术,对非结核性真菌细菌性肺病 (NTM-PD) 显示出希望. 需要更多的研究来填补NTM-PD管理中这些治疗方法的证据缺口.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 治疗非结核性菌根性肺病 (NTM-PD) 是复杂的,通常涉及长时间的抗生素疗程,并具有显著的副作用.
- 目前的指导方针提供了关于非药理方法的有限信息,尽管它们在慢性呼吸道疾病的症状管理和治疗结果方面的重要性很大.
研究的目的:
- 系统地审查关于NTM-PD的非药物干预的证据.
- 确定干预措施的影响,如气道清理,肺部康复,营养和心理支持.
主要方法:
- 按照系统性审查和元分析 (PRISMA) 准则的首选报告项目进行了系统性文献审查.
- 研究重点是针对NTM-PD患者的非药物干预措施.
主要成果:
- 对于在NTM-PD中进行非药理干预的证据有限.
- 三项研究报告了空气通道清除技术的积极影响 (例如,振荡的正气压,胸部物理治疗装置,胸部振荡装置,高压盐水雾化).
- 没有发现关于NTM-PD的营养支持,肺部康复或心理护理干预措施的研究.
结论:
- 非药物干预,特别是气道清理技术,在管理NTM-PD方面显示出潜力.
- 证据基础中的重大缺陷需要对NTM-PD患者的这些干预措施进行进一步的高质量研究.
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