相关实验视频
Updated: Jan 8, 2026

10:37
Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
9.9K
治疗慢性腹痛的内药物输送:一个案例系列
Harold Burke1,2, Michael Liu3, Salim M Hayek2
1Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Interventional pain medicine
|December 24, 2025
概括
内药物输送 (IDD) 在四名对其他治疗不耐药的患者中有效管理慢性腹痛 (CAP). 这种方法提供了持续的疼痛缓解和功能独立,没有阿片类药物.
科学领域:
- 疼痛医学 医学 疼痛医学
- 干预性疼痛管理 干预性疼痛管理
- 神经调节是一种神经调节.
背景情况:
- 慢性腹痛 (CAP) 影响了近3%的美国成年人,这给健康带来了重大挑战.
- 目前的干预程序,如交感神经阻塞和脊髓刺激,对于CAP显示出不同的疗效.
- 在CAP管理中,精确的诊断算法至关重要,以区分感应性疼痛与中央介导的疼痛.
研究的目的:
- 评估药物输入管内 (IDD) 治疗耐火性慢性腹痛 (CAP) 的有效性.
- 评估IDD作为满足GA ROME IVCAP标准的患者的替代治疗方法.
- 为了突出IDD的作用,在不那么入侵的干预措施失败后.
主要方法:
- 审查了四名耐火,非中央调解的CAP患者的病例系列.
- 患者接受了诊断性持续穿刺 (DDE) 来确认内脏/体内疼痛或根据临床病史进行IDD植入.
- 在永久植入之前,对大多数患者进行了连续的内导管试验.
主要成果:
- 在这四个案例中,内药物输送 (IDD) 均为耐火性CAP提供了有效的管理.
- 植入的持续时间从1.5年到10年不等,患者仍然没有阿片类药物.
- 患者在日常生活活动 (ADL) 和仪器ADL方面保持完全独立.
结论:
- 一旦排除了中心介导的疼痛,IDD是耐火性CAP的有希望的替代方案.
- 向性内治疗可提供持久的疼痛缓解和功能改善,用于内脏/nociceptive CAP.
- 与其他CAP干预疗法相比,这种方法可能会导致更少的并发症.
相关概念视频
Drug Delivery: Parenteral Route
1.4K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K
Local Anesthetics: Clinical Application as Epidural Anesthesia
661
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
661
Drugs for Treatment of Diarrhea-Predominant IBS
593
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
593
Drug Delivery: Miscellaneous Routes
692
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
692
Local Anesthetics: Clinical Application as Spinal Anesthesia
1.3K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.3K

