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Updated: Jan 8, 2026

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与里博西基利布治疗相关的 Vitiligo:一个罕见的病例报告
Zirui Wang1, Yuanrui Bai2, Rihan Wu2
1Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Frontiers in oncology
|December 24, 2025
概括
利博西克利布是一种CDK4/6抑制剂,在转移性乳腺癌患者中很少会引起白风. 这一案例凸显了潜在的免疫联系,以及对这种罕见的副作用的患者咨询的需要.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 利博西克利布是一种循环素依赖性激酶4/6 (CDK4/6) 抑制剂,用于转移性乳腺癌.
- 虽然已知血液和胃肠道毒性,但像白风这样的皮肤反应很少见.
- 本报告侧重于一种罕见的白风,由 ribociclib 诱导.
研究的目的:
- 报告一种由 ribociclib 诱导的白风样病变病例.
- 分析这种不良药物反应的潜在免疫媒介机制.
- 为了提高人们对这个未被认可的协会的认识.
主要方法:
- 一个59岁的患有转移性乳腺癌的女性,接受了 ribociclib/letrozole 的病例研究.
- 临床检查,皮肤镜检查和伍德的灯检查用于诊断.
- 治疗涉及局部莫梅松和塔克罗利斯.
主要成果:
- 患者在开始服用 ribociclib 16 个月后,出现了与非细分性白风一致的性低颜色斑块.
- 皮肤镜检查显示有色素损失和外周色素过多.
- 治疗稳定了病变,并继续使用 ribociclib 来控制瘤.
结论:
- 在HR阳性转移性乳腺癌患者中,ribociclib可能会诱导白风,发病时间可变.
- 这表明 ribociclib 和白风之间存在潜在的联系,可能是免疫介导的.
- 需要进一步的研究来确认因果关系,并建议患者就这种罕见的风险进行咨询.
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