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甘油三-葡萄糖指数预测了跨导管大动脉替换后的早期,短期和长期死亡率

Haitham Abu Khadija¹, Duha Najajra², Mohammad Masu'd²

¹Heart Center, Kaplan Medical Center, Rehovot, affiliated with the Hebrew University, Jerusalem, Israel.

American heart journal plus : cardiology research and practice

|December 24, 2025

概括

甘油三糖 (TyG) 指数预测了TAVR后的死亡率. 较高的TyG指数表明TAVR患者的早期,短期和长期死亡风险增加.

科学领域:

心脏病学心脏病学
代谢综合征是代谢综合征的一种.
医疗器械医疗器械

背景情况:

过导管大动脉置换 (TAVR) 改善了严重大动脉狭窄的结果,但有相关的死亡率.
甘油三糖指数 (TyG) 是胰岛素抵抗的标志物,可以识别高危人群.
这项研究调查了TAVR.之后的基线TyG指数对死亡率的预测值.

研究的目的:

为了确定基线甘油三糖 (TyG) 指数是否预测TAVR后30天,1年和3年的全因死亡率.
评估TyG指数作为TAVR受益人的风险分层工具.
确定与不同死亡时间点相关的特定TyG指数值.

主要方法:

在2010年至2024年期间,对821名接受TAVR的患者进行了回顾性研究.
从基线甘油三和葡萄糖水平计算TyG指数.
考克斯的比例危险模型和ROC曲线分析,以评估TyG指数与死亡率之间的关联.

主要成果:

较高的基线TyG指数与30天,1年和3年的全因死亡率增加显著相关.
泰格指数每增加1个单位就会增加1年死亡的风险 (aHR1.62),并预测30天 (HR1.92) 和3年死亡率 (HR1.42).
在ROC分析中,最佳的TyG值为30天的9.012,一年的9.15,三年死亡率为8.700.

结论:

基线TyG指数是TAVR后早期,短期和长期死亡率的独立预测指标.
人口特定的TyG切割点有助于对TAVR患者的代谢风险校准.
泰格指数作为一个简单的生物标志物,用于完善风险分层,并指导TAVR接受者的后续强度.

关键词:

胰岛素耐药性胰岛素耐药性是一种死亡率死亡率死亡率风险分层是指风险的分层.通过导管更换大动脉门.在TyG指数中,TyG是指数.

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