代谢组和转录组的整合分析揭示了脂多糖对卵巢对刺激反应的影响

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Xin Mu^1,2, Feng Zhu², Yudan Zhang²

¹Clinacal Department, The Assisted Reproductive Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, People's Republic of China.

Immunity, inflammation and disease

|December 24, 2025

概括

由脂聚糖 (LPS) 引起的炎症会损害卵巢对刺激的反应,影响卵细胞产量和代谢过程. 在这种有害的炎症反应中,IL-17信号通路似乎至关重要.

科学领域:

生殖生物学生殖生物学
代谢学代谢学代谢学
免疫学免疫学免疫学

背景情况:

脂聚糖 (LPS) 是格拉姆阴性细菌的关键成分,已知可诱导炎症反应.
控制性卵巢刺激 (COS) 是辅助生殖技术的基石.
了解炎症如何影响COS期间的卵巢功能对于改善治疗结果至关重要.

研究的目的:

研究LPS影响卵巢对COS的反应的分子机制.
分析不同代谢物和基因表达特征,以应对LPS暴露.
为了确定参与LPS诱导的卵巢功能障碍的关键信号通路.

主要方法:

雌性小鼠接受了LPS或对照治疗,并接受了COS.
卵巢组织和血液样本被收集用于代谢和转录组测序.
斯皮尔曼的相关性分析被用来将代谢物和信号通路中的基因表达联系起来.

主要成果:

暴露于LPS显著降低了第II元期卵细胞的数量和质量.
代谢分析揭示了卵巢组织和血清中碳水化合物,脂质和氨基酸代谢的变化.
基因表达分析表明脂质和类固醇代谢过程的下调,IL-17信号通路的显著作用.

结论:

由LPS引起的炎症对卵巢对COS的反应产生不利影响.
脂质,碳水化合物和氨基酸的代谢功能障碍与卵巢反应受损有关.
IL-17信号通路被认为是LPS诱导的卵巢损伤中的关键调解者.

关键词:

在LPS中使用LPS.相关性分析的相关性分析.代谢生物组的代谢生物组翻译学翻译学翻译学翻译学

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