在姐妹研究队列中,青春期的时间和发生子宫癌
Ariayana N Harrell1,2, Katie M O'Brien2, Natalie D Shaw3
1Department of Sociology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
International journal of cancer
|December 24, 2025
概括
较早的青春期发作,以较年轻的乳房发育 (larche) 和初潮 (menarche) 表示,与子宫癌风险增加有关. 这种关联在1950年以后出生的女性中尤其明显.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 癌症流行病学 癌症流行病学
- 妇女健康 妇女健康
背景情况:
- 初潮时的年龄较小是患子宫癌的已知危险因素.
- 早期青春期发育,以larche (乳腺发育) 为标志,意味着雌激素暴露,并可能影响子宫癌风险.
- 在larche年龄的下降与子宫癌率的上升并行,这表明存在潜在的联系.
研究的目的:
- 调查larche和初潮时的年龄与子宫癌的发病率之间的联系.
- 通过出生队列,种族,儿童体重和成人BMI来探索这种关联的潜在修改.
主要方法:
- 利用了美国姐妹研究队列中的34,152名妇女的数据 (2003-2009年入学).
- 采用多变量调整的考克斯比例危险回归来分析在larche和 menarche时的自我报告年龄.
- 进行了分层分析,以评估不同的人口和健康因素的影响度量修改.
主要成果:
- 在larche (HR: 0.91,95%CI: 0.85-0.97) 和 menarche (HR: 0.90,95%CI: 0.84-0.96) 的1年年龄增加与子宫癌发病率相反相关.
- 这些反向关联主要在1950年或以后出生的女性中观察到.
- 根据种族,童年体重或成人BMI,没有发现关联的显著变化.
结论:
- 在larche和初潮时的年龄较小,表明早期和潜在的长期青春期雌激素暴露,可能会增加对子宫癌的易感性.
- 这些发现强调了青春期时间在子宫致癌的重要性,特别是在最近出生的人群中.
- 进一步的研究可能会阐明早期青春期与子宫癌风险之间的联系背后的机制.
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