免疫疗法期间肺癌患者的循环节强度下降与疾病进展和死亡风险增加有关
Louise Strøm1,2, Ali Amidi1,2, Lisa M Wu1,2,3,4
1Unit for Psycho-Oncology and Health Psychology, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark.
Journal of biological rhythms
|December 24, 2025
概括
昼夜节律强度的破坏与非小细胞肺癌患者的进展和死亡风险增加有关. 稳定昼夜节律可能会改善结果和癌症治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
- 时间生物学 时间生物学
背景情况:
- 睡眠和昼夜节律障碍在癌症患者中很普遍,可能会影响预后.
- 这些干扰与现代癌症疗法 (如免疫检查点抑制剂 (ICI)) 的结果相比,研究不足.
研究的目的:
- 研究睡眠和昼夜节律轨迹与非小细胞肺癌 (NSCLC) 患者的预后结果之间的关系.
- 探索昼夜节律作为NSCLC临床结果的可修改生物标志物的潜力.
主要方法:
- 对49名未经治疗的NSCLC患者进行了前性纵向研究.
- 收集了24小时昼夜功能指数 (CFI) 记录和每周失眠严重程度指数 (ISI) 评估.
- 从睡眠日记和使用考克斯回归分析的预后结果估计的总睡眠时间 (TST).
主要成果:
- 较低的中值昼夜强度轨迹与早期疾病进展 (HR=3.75) 和死亡 (HR=3.07) 的风险显著增加有关.
- 在失眠严重程度 (ISI) 或总睡眠时间 (TST) 和预后结果之间没有发现显著的关联.
- 昼夜强度的下降与疾病进展和死亡率的风险增加有关.
结论:
- 循环节律的强度,而不是失眠的严重程度或睡眠时间,是NSCLC患者的显著预后因素.
- 研究结果表明,昼夜节律稳定可能是改善患者治疗结果和ICI疗效的目标.
- 需要进一步的干预研究来验证这些发现并探索治疗策略.
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