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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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壁切压力和振荡切压指数独立地与复杂的动脉斑块有关

Jonathan Andrae1, Andreas Schindler2, Christoph Strecker1

  • 1Department of Neurology and Neurophysiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

European heart journal. Cardiovascular Imaging
|December 24, 2025
PubMed
概括

男性性别,较高的缩壁切削应力 (WSS) 和较低的振荡切削指数 (OSI) 与患有内动脉狭窄症 (ICA) 患者的复杂性动脉斑块 (cCAP) 有关. 这些因素有助于中风风险分层.

关键词:
4D 流动MRI 4D 流动MRI是指四维的流动MRI.动脉样硬化 动脉样硬化血液动力学 血液动力学斑块成像检测 斑块成像检测斑块的脆弱性 斑块的脆弱性预防中风 预防中风

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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Shearing Stress01:19

Shearing Stress

Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
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Components of Stress

Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
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Stress: General Loading Conditions01:15

Stress: General Loading Conditions

To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
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Thin-Walled Hollow Shafts01:15

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In analyzing a thin-walled hollow shaft subjected to torsional loading, a segment with width dx is isolated for examination. Despite its equilibrium state, this segment faces torsional shearing forces at its ends. These forces are quantitatively described by the product of the longitudinal shearing stress on the segment's minor surface and the area of this surface, leading to the concept of shear flow. This shear flow is consistent throughout the structure, indicating a uniform distribution of...
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Principal Stresses01:24

Principal Stresses

The graphical depiction of normal and shearing stress equations is represented by a circle, demonstrating the interplay between these stresses under different angular conditions. The center of this circle C, located on the vertical axis, represents the average normal stress, while its radius shows the range of stress variations. At points A and B, where the circle intersects the horizontal axis, the maximum and minimum normal stresses are observed, occurring without shearing stress. These...
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