Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

521
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
521
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

674
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
674
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The predictive power of neuropsychological measures in MCI: early detection of dementia conversion.

Frontiers in aging neuroscience·2026
Same author

Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Clinical Impact and Prognostic Value of Alzheimer Disease Biomarkers in the Very Old.

Neurology·2026
Same author

Naming performance in bilinguals with Alzheimer's disease and mild cognitive impairment.

Journal of Alzheimer's disease : JAD·2026
Same author

Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome-associated Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Appropriate use recommendations of the Spanish Society of Neurology's Behavioural Neurology and Dementia Study Group on anti-amyloid antibodies in the treatment of Alzheimer disease.

Neurologia·2026
Same journal

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Plasma-based neurobiological protein biomarkers as predictors of dementia progression: Insights from longitudinal aging study in India - Diagnostic assessment of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Sonia Sirisi Dolcet1,2, Érika Sánchez-Aced1,2, Olivia Belbin1,2

  • 1Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

新型抗体揭示了细胞内APP C端片段 (iAPP) 在阿尔茨海默氏症中积累.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 神经病理学神经病理学
  • 分子生物学分子生物学

背景情况:

  • 在阿尔茨海默病 (AD) 大脑中观察到粉样前体蛋白 (APP) C端片段 (CTF) 的积累.
  • 以前的研究依赖于生化技术,使得人类AD中APP-CTF积累的神经解剖学分布未知.
  • 开发了一种新的APP抗体,以研究死后人类脑组织中APP-CTF积累的形态分布.

研究的目的:

  • 为了生成和表征一种针对APP的C端的新型抗体.
  • 研究人类AD大脑中APP-CTF积累的神经解剖学分布和形态特征.
  • 确定APP-CTF积累是否代表AD的神经病理学标志.

主要方法:

  • 产生了一种针对APP.的C末端的新型小鼠抗体 (APP1B).
  • 通过使用唐氏综合征 (DS) 胎儿的初级人类皮质细胞培养物和表达APP-C99.9的细胞系验证的抗体特异性.
  • 在死后的人类大脑样本上进行免疫组织化学检查,这些样本来自患有阿尔茨海默氏症 (零散性,自体主导性和DS-AD) 的个人,对照者和其他神经退行性疾病.

主要成果:

  • 新型APP1B抗体在细胞培养中专门识别了APP-CTFs.
  • 广泛的细胞内"状"神经元APP (iAPP) 免疫活性在不同类型的ADAD中观察到AD易受伤害的大脑区域.
  • 控制组中没有iAPP病理,没有AD的DS和其他神经退行性疾病,并且没有与或无处不在的合.

结论:

  • 细胞内 APP C端片段 (iAPP) 病理被提议作为阿尔茨海默氏病的一个新的神经病理学标志.
  • 图形分布和iAPP病理的选择性神经元参与表明了APP复合和tau聚合之间的联系.
  • 这一发现提供了对AD病原体背后的分子机制的新见解.