基础科学和病原发生学
Pietro Michelucci1, Lisa Gusman1, Laura Onac1
1Human Computation Institute, Ithaca, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
公民科学使公众志愿者能够为阿尔茨海默病的研究注释大脑图像. 这种群众驱动的方法实现了专家级准确性,有助于机器学习的发展.
科学领域:
- 神经科学是一个神经科学.
- 病理学 病理学 病理学
- 公民科学 公民科学
背景情况:
- 来自整个幻灯片图像 (WSIs) 的研究级的病学注释需要高质量的数据,超出目前的自动化方法.
- 公民科学将公众志愿者作为研究合作者,提供一种可扩展的方式,以获得专家类型的组织病理学评估.
- 这种方法可以加强社区外展和教育,特别是在受阿尔茨海默病影响不成比例的人群中,比如西班牙裔社区.
研究的目的:
- 试验人类计算方法,让公众志愿者参与注释人类大脑WSIs中的粉样蛋白病理.
- 用"群众智慧"方法对比基于群众的两阶段分析,与专家生成的特定病理的黄金标准数据进行比较.
主要方法:
- 一个由人群驱动的分析管道将他的病理学分析分解为非专家志愿者可管理的在线任务.
- "群众智慧"方法将多个单独的注释汇总为每个病理实例的单个专家类注释.
- 这项研究将基于人群的分析与核心斑块和脑粉样血管病变的黄金标准数据进行了比较.
主要成果:
- 测试了方法开发,包括注释接口和共识方法.
- 充分聚合非专家答案,与黄金标准数据达成一致,满足或超过专家互评分协议.
- 这表明了使用公民科学用于病理学注释的可行性.
结论:
- 开发的方法促进了神经退行性疾病研究中机器学习的快速,大量的注释数据集生产.
- 试验结果支持开发一个在线平台,由志愿者对人类大脑组织病理学的新分析.
- 该平台将包括对受影响社区 (如西班牙裔人口) 的文化响应宣传,以促进研究人员的参与.
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