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基础科学和病原发生学

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肠道微生物组的改变与巴西老年人的阿尔茨海默病 (AD) 进展有关. 在认知阶段观察到便微生物的变化,这表明肠道微生物群在衰老和神经退行中起着作用.

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科学领域:

  • 微生物组研究的研究.
  • 神经科学是一个神经科学.
  • 老龄化研究研究.

背景情况:

  • 长寿受到遗传学,生活方式和环境的影响,这些因素可以改变微生物群.
  • 微生物群的变化可能会影响对阿尔茨海默病 (AD) 和认知能力下降的易感性.
  • 假设:老年人微生物组合与AD临床阶段相关.

研究的目的:

  • 在巴西长寿人口中调查口腔和肠道微生物群.
  • 检查AD连续性的微生物群和认知障碍之间的关系.
  • 在认知正常 (CU),轻度认知障碍 (MCI) 和AD个体中表征微生物差异.

主要方法:

  • 12名来自巴西长寿热点的老年人 (>65岁) 的试点研究.
  • 使用临床痴呆症评分 (CDR) 尺度进行临床认知评估.
  • 唾液和便样本的16S rRNA基因测序 (V3-V4区域),分析使用DADA2和SILVA进行分类学分配.

主要成果:

  • 跨组相似的α多样性;减少了MCI的唾液丰富度.
  • 便PCoA显示出明显的组分离 (MCI/AD类似);唾液样本更为均.
  • 在MCI/AD.中的便类 (Bacillota, Bacteroidota, Pseudomonadota) 和属 (Bacteroides, Blautia, Faecalibacterium) 的变化.
  • 在AD组中,便中Streptococcus的增加仅限于AD组.
  • 唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中. 在MCI/AD.中,唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中. 在MCI/AD.中,唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中. 在MCI/AD.中,唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中.

结论:

  • 便微生物群在AD连续线上表现出临床阶段特定的变化.
  • 唾液微生物群看起来更稳定,表明了不同的微生物适应.
  • 微生物组的变化在衰老和神经退行中突出表现,可能会影响弹性.