基础科学和病原发生学
Amanda Muliterno Domingues Lourenço de Lima1, Marco De Bastiani1, Wyllians Vendramini Borelli1
1Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
肠道微生物组的改变与巴西老年人的阿尔茨海默病 (AD) 进展有关. 在认知阶段观察到便微生物的变化,这表明肠道微生物群在衰老和神经退行中起着作用.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 老龄化研究研究.
背景情况:
- 长寿受到遗传学,生活方式和环境的影响,这些因素可以改变微生物群.
- 微生物群的变化可能会影响对阿尔茨海默病 (AD) 和认知能力下降的易感性.
- 假设:老年人微生物组合与AD临床阶段相关.
研究的目的:
- 在巴西长寿人口中调查口腔和肠道微生物群.
- 检查AD连续性的微生物群和认知障碍之间的关系.
- 在认知正常 (CU),轻度认知障碍 (MCI) 和AD个体中表征微生物差异.
主要方法:
- 12名来自巴西长寿热点的老年人 (>65岁) 的试点研究.
- 使用临床痴呆症评分 (CDR) 尺度进行临床认知评估.
- 唾液和便样本的16S rRNA基因测序 (V3-V4区域),分析使用DADA2和SILVA进行分类学分配.
主要成果:
- 跨组相似的α多样性;减少了MCI的唾液丰富度.
- 便PCoA显示出明显的组分离 (MCI/AD类似);唾液样本更为均.
- 在MCI/AD.中的便类 (Bacillota, Bacteroidota, Pseudomonadota) 和属 (Bacteroides, Blautia, Faecalibacterium) 的变化.
- 在AD组中,便中Streptococcus的增加仅限于AD组.
- 唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中. 在MCI/AD.中,唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中. 在MCI/AD.中,唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中. 在MCI/AD.中,唾液变化包括Prevotellaceae,Streptococcaceae,Prevotella,Streptococcus,Haemophilus和Neisseria在MCI/AD.中.
结论:
- 便微生物群在AD连续线上表现出临床阶段特定的变化.
- 唾液微生物群看起来更稳定,表明了不同的微生物适应.
- 微生物组的变化在衰老和神经退行中突出表现,可能会影响弹性.
相关概念视频
Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology
524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis
676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection
64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K


