生物标志物 生物标志物
Hadrien M Lalive1, Federica Ribaldi1,2, Augusto J Mendes1,2
1Geneva Memory Center, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
大脑粉样血管病变 (CAA) 影响29%的阿尔茨海默病 (AD) 患者,显示出类似的认知功能和AD生物标志物,无论CAA的概率如何. 这凸显了需要在记忆诊所设置中对波士顿标准进行进一步研究的需要.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
背景情况:
- 脑粉样蛋白血管病变 (CAA) 诊断对于接受抗粉样蛋白免疫治疗的阿尔茨海默病患者至关重要,因为它与粉样蛋白相关的成像异常有关.
- 波士顿标准是识别可能的CAA在记忆诊所的标准,但其在认知障碍AD患者的患病率和特征尚未明确.
研究的目的:
- 用更新的波士顿标准 (v2.0) 确定认知障碍,生物标志物确认的AD患者中CAA的患病率.
- 为了比较AD患者与没有CAA之间的认知,临床和生物标志物概况.
主要方法:
- 从一个记忆中心数据库 (2012年6月 - 2024年7月) 追溯分析了415名可能患有AD的患者 (生物标志物确认).
- 放射科医生和图像分析师 (对临床数据视而不见) 审查了MRI扫描,神经科医生证实了诊断.
- 使用波士顿标准将患者分为CAA的高 (AD-CAA) 或低 (AD-nCAA) 概率;使用统计测试比较特征.
主要成果:
- 29%的AD患者被归类为AD-CAA,而71%的患者是AD-nCAA.
- 认知严重程度,全球认知,口头情节性记忆和执行功能在AD-CAA和AD-nCAA组之间是可比的.
- AD-CAA患者年龄较大,更有可能使用抗血小板治疗,心血管疾病患病率较高,但心血管风险因素和AD生物标志物概况相似.
结论:
- 通过波士顿标准确定的AD患者中CAA的患病率低于基于病理学的估计.
- 在记忆诊所的AD患者可能具有相似的认知特征和AD生物标志物模式,无论他们的CAA概率如何.
- 进一步的研究对于验证波士顿标准在AD的记忆诊所人群中的应用至关重要.
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