Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A lifespan staging model of basal forebrain cholinergic vulnerability.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.

Nature communications·2026
Same author

From adaptive to maladaptive myelination: White matter dynamics in cognition and neurologic disorders.

Neuroscience and biobehavioral reviews·2026
Same author

Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Cardiac [<sup>18</sup>F]fluoroethoxybenzovesamicol uptake is not specific to vesicular acetylcholine transporter in mice and pigs.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2026
Same author

Citric acid water as an alternative to food restriction to motivate task performance in mice during touchscreen testing.

Lab animal·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Alycia M Crooks1,2,3,4, Kate M Onuska1,2,3,4, Taylor W Schmitz1,2,3,4

  • 1Lawson Health Research Institute, London, ON, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

胆固醇信号的早期缺陷,特别是囊泡性乙胆转运器 (VAChT) 功能减少,与阿尔茨海默病模型中的空间记忆障碍有关,在显著的斑块积累之前. 这表明向胆固醇功能障碍可能是关键的治疗策略.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 阿尔茨海默氏症疾病研究研究
  • 突触性可塑性 突触性可塑性

背景情况:

  • 阿尔茨海默病 (AD) 病理包括粉样β (Aβ) 和,但目前针对Aβ的疗法对认知益处有限.
  • 基础前脑胆能神经元的损失先于AD病理和神经退行.
  • 膀性乙胆转运体 (VAChT) 调节乙胆 (ACh) 的分泌,并在AD大脑的早期减少.

研究的目的:

  • 在AD小鼠模型中研究早期胆固醇突触功能障碍和海马体依赖的认知缺陷之间的联系.
  • 确定是否减少VAChT功能有助于空间记忆障碍在显著的Aβ斑块积累之前.

主要方法:

  • 使用了APPNL-F小鼠模型来表达人性化的Aβ.
  • 在海马体CA1区域使用光纤测量和GRABACh传感器记录了乙胆 (ACh) 信号.
  • 使用Trial-Unique延迟不匹配到位置 (TUNL) 任务评估空间工作记忆.

主要成果:

  • 随着年龄的增长,VAChT水平下降,胆固醇度在回应奖励时显著降低.
  • 年轻的APPNL-F小鼠在实质性斑块形成之前,表现出空间工作记忆缺陷.
  • 这些记忆缺陷与减少胆固醇反应和在VAChT淘汰小鼠中观察到的镜像功能障碍相关.

结论:

  • 胆突触功能的早期缺陷先于明显的AD病理,并与空间记忆障碍有关.
  • 这些发现凸显了胆固醇信号在早期AD病变发生过程中的关键作用.
  • 未来的研究将专注于恢复记忆和胆固醇调的策略.