Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Spatiotemporal dynamics of tau extent and load increase in Alzheimer's disease across four longitudinal cohorts.

Nature aging·2026
Same author

Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia.

European journal of neurology·2026
Same author

Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy.

JAMA network open·2026
Same author

CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum.

EBioMedicine·2026
Same author

Sex-specific associations between astrocytic reactivity and cognitive decline in unimpaired elderly.

bioRxiv : the preprint server for biology·2026
Same author

Prognostic value of plasma brain-derived pTau.

medRxiv : the preprint server for health sciences·2026

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Michael H Malek-Ahmadi1,2,3, Savar Sharma4, Fawaz Stipho5

  • 1Banner Alzheimer's Institute, Phoenix, AZ, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括

化化tau-217 (ptau-217) 试验在识别未经认知障碍的个体中临床前阿尔茨海默病 (AD) 时显示出极好的准确性. 对于ptau-217差异的巨大效果大小支持其作为临床前AD的诊断工具的使用.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经退行性疾病的生物标志物
  • 阿尔茨海默病的诊断阿尔茨海默病的诊断.
  • 临床蛋白质组学 临床蛋白质组学

背景情况:

  • 血酸化tau-217 (ptau-217) 与体内阿尔茨海默氏症 (AD) 病理学有很强的相关性.
  • 对于ptau-217测试对具有或没有AD病理的认知正常 (CU) 个体进行区分的能力,需要进一步评估.

研究的目的:

  • 为了评估粉素阳性和粉素阴性CU老年人之间的ptau-217水平的平均差异.
  • 评估ptau-217的诊断准确性,以确定CU个体的临床前AD.

主要方法:

  • 在PubMed,Embase和Ebsco数据库中进行系统的文献搜索,截至2024年8月1日.
  • 对14项研究 (5,763名参与者) 的分析,以使用Hedge的g.
  • 对9项研究 (3,626名参与者) 的元分析,以使用曲线下的积分面积 (AUC) 来确定诊断准确性.

主要成果:

  • 在粉胺阳性和粉胺阴性CU个体之间的ptau-217平均差异中观察到一个很大的效果大小 (Hedge's g = 1.45),具有很高的异质性.
  • 汇总的AUC为0.84,表明ptau-217的诊断准确度很好,用于识别粉胺阳性CU个体.
  • 按测定平台,粉样蛋白检测方法和研究环境进行的子组分析没有显著改变主要发现.

结论:

  • 血ptau-217测定在识别阿尔茨海默氏症临床前阶段的个体方面具有很高的准确性.
  • 对于ptau-217水平的显著平均差异进一步验证了其作为临床前AD的诊断生物标志物的实用性.