生物标志物 生物标志物
1University of Glasgow, Glasgow, Glasgow, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
心血管疾病风险和阿尔茨海默病 (AD) 的血液生物标志物与认知障碍 (CI) 有关. 然而,心血管疾病风险并不能缓解这些生物标志物和CI之间的关联,这表明存在独立的风险因素.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 心血管健康 心血管健康
背景情况:
- 基于血液的生物标志物有可能彻底改变阿尔茨海默病 (AD) 的诊断和预后.
- 心血管疾病 (CVD) 风险因素如高血压和糖尿病与认知障碍 (CI) 和痴呆症有关.
- 与CI相关的CVD风险和基于血液的AD生物标志物之间的相互作用需要进一步调查.
研究的目的:
- 调查心血管疾病风险是否能显著缓和血型AD生物标志物与CI之间的关系.
- 探索CVD风险和AD生物标志物对认知功能的独立和联合影响.
主要方法:
- 包括来自Bio-Hermes研究的661名参与者 (395名CI,266名认知正常).
- 使用动脉样硬化心血管疾病 (ASCVD) 风险评分计算心血管疾病风险.
- 对阿尔茨海默病生物标志物 (Aβ42/Aβ40,p-tau181,p-tau217,Apoε4) 和心血管疾病风险进行了后勤回归分析,测试心血管疾病风险的适度.
主要成果:
- 血型生物标志物和心血管疾病风险都与CI有显著的关联.
- 血p-tau217显示了与CI (OR=2.34) 最强的关联.
- 心血管疾病风险调节了p-tau181和CI之间的关系,但其他生物标志物没有.
结论:
- 基于血液的痴呆症生物标志物和心血管疾病风险与CI独立相关.
- 心血管疾病风险评估应补充痴呆症生物标志物评估,以准确预后.
- 鉴于痴呆症的全球影响,了解多种风险因素至关重要.
相关概念视频
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