生物标志物 生物标志物
Mahir Tazwar1, Arnold M Evia2, Abdur Raquib Ridwan2
1Illinois Institute of Technology, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
研究人员开发了MARBLE,这是一种基于MRI的自动化标志物,用于临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC). 这种工具显示出在老年人中LATE-NC的体内诊断和监测的潜力.
科学领域:
- 神经成像是一种神经成像.
- 神经病理学神经病理学
- 老年医学 老年医学
背景情况:
- 临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 是老年大脑的常见发现,但确切的诊断需要尸检.
- 目前的诊断局限性要求开发用于LATE-NC的体内标记物.
- 这项研究的重点是确定可靠的MRI特征,以在社区的老年人中检测LATE-NC.
研究的目的:
- 开发和验证一个自动化的,in-vivo磁共振成像 (MRI) 标志物用于临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC).
- 使用MRI衍生特征区分LATE-NC的早期和高级阶段.
- 将开发的标记物包装成用户友好的软件,以实现潜在的临床应用.
主要方法:
- 利用了从纵向衰老研究中获得的ex-vivoMRI,in-vivoMRI和神经病理学数据.
- 开发了一个两级堆叠分类器,使用分数异构 (FA),基于变形的形态学 (DBM) 和体积来识别LATE-NC.
- 在体内验证了分类器,并将管道包装成一个名为MARBLE (MARker of Brain LatE) 的自动化软件容器.
主要成果:
- 活体分类器实现了AUC为0.85 (77%的平衡精度) 区分LATE-NC阶段.
- 在MARBLE标记物的体内验证表明,测试组的AUC为0.76.
- 较高的MARBLE分数与晚期NC阶段的进展有显著的相关性 (p < 0.001).
结论:
- MARBLE是一种新的,自动化的,体内MRI标记器,用于LATE-NC,具有有前途的诊断性能.
- 该工具在广泛的ex-vivo数据上进行了训练,并在in-vivo中得到了验证,显示了临床实用性的潜力.
- 需要在独立队列中进一步验证,但MARBLE可以帮助LATE-NC诊断,监测和治疗开发.
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