Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Diffusion abnormalities associated with brain arteriolosclerosis: An in-vivo MRI and pathology study in community-based older adults.

Neurobiology of aging·2026
Same author

Automated detection of cerebral microbleeds on ex-vivo MRI scans of community-based older adults.

NeuroImage·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Mahir Tazwar1, Arnold M Evia2, Abdur Raquib Ridwan2

  • 1Illinois Institute of Technology, Chicago, IL, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了MARBLE,这是一种基于MRI的自动化标志物,用于临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC). 这种工具显示出在老年人中LATE-NC的体内诊断和监测的潜力.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经成像是一种神经成像.
  • 神经病理学神经病理学
  • 老年医学 老年医学

背景情况:

  • 临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 是老年大脑的常见发现,但确切的诊断需要尸检.
  • 目前的诊断局限性要求开发用于LATE-NC的体内标记物.
  • 这项研究的重点是确定可靠的MRI特征,以在社区的老年人中检测LATE-NC.

研究的目的:

  • 开发和验证一个自动化的,in-vivo磁共振成像 (MRI) 标志物用于临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC).
  • 使用MRI衍生特征区分LATE-NC的早期和高级阶段.
  • 将开发的标记物包装成用户友好的软件,以实现潜在的临床应用.

主要方法:

  • 利用了从纵向衰老研究中获得的ex-vivoMRI,in-vivoMRI和神经病理学数据.
  • 开发了一个两级堆叠分类器,使用分数异构 (FA),基于变形的形态学 (DBM) 和体积来识别LATE-NC.
  • 在体内验证了分类器,并将管道包装成一个名为MARBLE (MARker of Brain LatE) 的自动化软件容器.

主要成果:

  • 活体分类器实现了AUC为0.85 (77%的平衡精度) 区分LATE-NC阶段.
  • 在MARBLE标记物的体内验证表明,测试组的AUC为0.76.
  • 较高的MARBLE分数与晚期NC阶段的进展有显著的相关性 (p < 0.001).

结论:

  • MARBLE是一种新的,自动化的,体内MRI标记器,用于LATE-NC,具有有前途的诊断性能.
  • 该工具在广泛的ex-vivo数据上进行了训练,并在in-vivo中得到了验证,显示了临床实用性的潜力.
  • 需要在独立队列中进一步验证,但MARBLE可以帮助LATE-NC诊断,监测和治疗开发.