和长脉冲宽度刺激 (TLPS) 对脊髓损伤后的肌肉和心脏代谢风险因素:试点随机试验
Ashraf S Gorgey1,2, Refka E Khalil1, Ahmad Alazzam1
1Spinal Cord Injury and Disorders, Central Virginia VA Medical Center, Richmond, VA 23249, USA.
Cells
|December 24, 2025
概括
治疗加长脉冲宽度刺激 (LPWS) 显示,脊髓损伤 (SCI) 患者的直腿肌肉大小适度增加. 这种方法可能有助于降低肌肉缩基因的调节,并改善代谢健康.
科学领域:
- 神经学 神经学
- 肌肉生理学 肌肉生理学
- 代谢健康 代谢健康
背景情况:
- 长脉冲宽度刺激 (LPWS) 在脊髓损伤 (SCI) 中提供了肌肉刺激的潜力.
- 研究丸激素治疗 (TT) 与LPWS结合,以增强骨肌肉大小,腿质量和SCI患者的代谢健康.
研究的目的:
- 评估TT + LPWS联合治疗一年的有效性,降低肌肉缩基因表达的调节,提高肌肉缩和线粒体健康的调节,在SCI患者中具有下部运动神经元 (LMN) 损伤.
主要方法:
- 10名患有慢性脑脊髓损伤的SCI参与者被随机分配到两个组,12个月:TT + LPWS (n=5) 或TT + 标准神经肌肉电刺激 (NMES) (n=5).
- 测量包括身体组成 (MRI,DXA),新陈代谢率,碳水化合物/脂质概况以及肌肉活检以检测基因表达和线粒体功能.
主要成果:
- 在6个月后,在TT + LPWS组中观察到腿直体 (RF) 肌肉截面面积 (CSA) 增加了25%.
- 趋势表明TT + LPWS的肌肉内和内脏脂肪组织 (VAT) 减少.
- TT + LPWS显示肌肉缩基因 (MURF1,FOXO3) 的趋势下降.
结论:
- 试点数据证实了LPWS在SCI患者中的安全性.
- 六个月的TT + LPWS导致RF肌肉CSA的适度增加.
- 信号通路分析表明,LPWS降低了肌肉缩通路的调节,因此需要进一步研究以家庭为基础的,更频繁的应用.
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