Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.1K
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.4K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.9K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.9K
Tumor Progression02:07

Tumor Progression

7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Molecular changes during AT/RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes.

Acta neuropathologica·2026
Same author

Needle-track metastasis in diffuse intrinsic pontine glioma: Need for a standardized surgical strategy?

Neuro-oncology advances·2026
Same author

Deep Learning Predicts Mutations and Outcomes in Gastrointestinal Stromal Tumors from Whole-Slide Images.

Cancer research·2026
Same author

Treatment effect heterogeneity of radiotherapy in localized Ewing sarcoma: A secondary analysis of the EURO-E.W.I.N.G. 99 and Ewing 2008 trial.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Prognostic Value of Regnase-1 in High-Grade Soft Tissue Sarcoma: Favourable in UPS, Yet Inverted in Adjuvantly Irradiated Patients.

Cancers·2026
Same author

VGLL3-Rearranged Spindle Cell Rhabdomyoblastic Tumor: A Clinicopathologic and Molecular Genetic Study of 18 Cases With Consistently Indolent Behavior.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026

相关实验视频

Updated: Jan 7, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.2K

SS18::SSX和BRD9调节共肉瘤的分化

Anna Kuntze1, Victor Banerjee2, Marcel Trautmann1

  • 1Gerhard-Domagk-Institute of Pathology, University Hospital Münster, 48149 Münster, Germany.

Cells
|December 24, 2025
PubMed
概括

突肉瘤 (SySa) 是由SS18::SSX驱动的,它影响BAF复合体和细胞分化. 这项研究揭示了SS18::SSX和BRD9调节上皮层-介质细胞过渡 (EMT) 因素,影响SySa瘤表型.

关键词:
在BAF复杂的 BAF复杂.这就是BRD9的原因.在E-Cadherin中使用.在EMT中,EMT是EMT.GBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFGBAFSS18::SSXX 这是一个SS18::SSX牛:一个牛.牛牛牛牛牛牛牛不同化的差异化差异化.突性肉瘤 (Synovial Sarcoma) 是一个突性肉瘤.

更多相关视频

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.6K

相关实验视频

Last Updated: Jan 7, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.2K
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.6K

科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 突肉瘤 (SySa) 是一种由SS18::SSX融合蛋白驱动的软组织恶性瘤.
  • 这种融合蛋白影响BAF染色体重塑复合体,改变基因转录,导致瘤异质.
  • 目前的治疗方法有效性有限,需要对SySa的分子机制有更深入的了解.

研究的目的:

  • 调查SS18::SSX和特定BAF子单元在SySa分化中的作用.
  • 探索这些成分如何调节上皮质-介质细胞过渡 (EMT) 和相关因素.

主要方法:

  • 纳米链分析用于评估在沉默SS18::SSX和BRD9.9时的基因表达变化.
  • 分析了已发表的单细胞RNA测序数据,以验证发现.
  • 专注于SS18::SSX,BRD9,EMT因子 (Snail,Slug) 和E-Cadherin表达的研究.

主要成果:

  • 沉默SS18::SSX和GBAF亚单元BRD9调节的SySa细胞分化通路.
  • SS18::SSX和BRD9都调节了与EMT相关的因素.
  • SS18:SSX被确定为抑制E-Cadherin表达的抑制剂,这是一个关键的EMT标记物.

结论:

  • SS18::SSX和BRD9在监管SySa的EMT关键参与者方面发挥着至关重要的作用.
  • 这些相互作用为多层调节瘤表型和潜在的SySa.预后提供了新的见解.
  • 了解这些机制可能有助于开发新型治疗策略.