核心体温与全脑灰质负相关:全球变暖背景下的试点研究
Keisuke Kokubun1, Kiyotaka Nemoto2, Yoshimitsu Yamamoto3
1Graduate School of Management, Kyoto University, Kyoto 606-8501, Kyoto, Japan.
Brain sciences
|December 24, 2025
概括
较高的核心体温与健康成年人灰质体积 (GMV) 的减少有关. 这项试点研究表明,微妙的温度变化会影响大脑结构,可能是由于炎症或氧化应激.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 人体生理学 人体生理学
背景情况:
- 全球变暖带来了生理风险,但其对大脑结构的影响尚不清楚.
- 核心体温的变化可能会影响大脑形态.
研究的目的:
- 为了研究核心体温和全脑灰质体积 (GMV) 在健康成年人之间的关联.
- 探索潜在的神经机制,连接体温和大脑结构.
主要方法:
- 在27名健康成年人身上进行了MRI扫描和核心温度评估.
- 相关性和部分相关性分析检查了核心体温和GMV之间的关系.
- 本杰明尼-霍赫伯格错误发现率用于多重比较校正.
主要成果:
- 在核心体温和全脑GMV之间发现了显著的负相关性 (r = -0.496,p = 0.009).
- 在共变量调整 (r = -0.373,p = 0.060) 后,趋势级显著的部分相关性仍然存在.
- 左侧状回旋与核心体温 (r = -0.643,p < 0.001) 有显著的负相关性.
结论:
- 正常生理体温的微妙变化可能与全球大脑结构的差异有关.
- 潜在的机制包括热引起的炎症,氧化应激和增加的神经代谢负荷.
- 研究结果表明,在环境温度上升的背景下,对理解大脑健康有意义.
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