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在老年患者的结肠直肠癌切除后的结果.

Richard Grainger1, Tatiana S Temperley1, Hugo C Temperley1,2,3

  • 1Department of Surgery-Trinity college Dublin/St James Hospital Dublin Ireland D08 NHY1 Dublin, Ireland.

Current oncology (Toronto, Ont.)
|December 24, 2025
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概括

75岁及以上患者的结肠直肠癌手术具有可接受的结果. 高查尔森并发症指数 (CCI) 评分预测并发症,而微创手术可能会改善结果.

关键词:
结肠直肠癌是什么意思伴随性疾病发生率.年长的老人老年人老年人.脆弱 脆弱 脆弱 脆弱 脆弱术后并发症 术后并发症外科手术的结果.

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科学领域:

  • 老年人手术是一门老年人手术.
  • 手术瘤学手术瘤学
  • 研究成果 研究成果 研究成果

背景情况:

  • 患有结直肠癌 (CRC) 的老年患者 (≥75岁) 在结局研究中代表性不足.
  • 准确的风险分层对于这一群体的手术决策至关重要.
  • 查尔森并发症指数 (CCI) 是评估并发症负担的关键工具.

研究的目的:

  • 评估75岁及以上患者结直肠癌切除术的结果.
  • 评估查尔森并发症指数 (CCI) 对这一群体不良结果的预测值.
  • 确定手术方法对结果的影响.

主要方法:

  • 对211名接受CRC切除的患者 (≥75岁) 的回顾性审查 (2019年1月至2024年9月).
  • 主要结局:主要手术后并发症 (Clavien-Dindo等级≥3) 或30天死亡率的组合.
  • 按CCI分层 (≥5与<5);分析包括千平方,费舍尔精确和曼-惠特尼U测试.

主要成果:

  • 平均年龄为81岁;24.6%的CCI≥5.
  • 患有CCI≥5的患者的重大并发症或30天死亡率明显更高 (29.4%对11.9%,p=0.04).
  • 腹腔镜切除具有独立的保护性 (aOR 0.37,p=0.048);年龄≥85岁和紧急呈现并不是显著的预测因素.

结论:

  • 75岁以上的患者的结肠直肠切除与可接受的发病率和低死亡率有关.
  • CCI ≥5是老年CRC患者不良结果的显著预测指标.
  • 微创手术可能为这个高风险群体带来优势.