在老年患者的结肠直肠癌切除后的结果
Richard Grainger1, Tatiana S Temperley1, Hugo C Temperley1,2,3
1Department of Surgery-Trinity college Dublin/St James Hospital Dublin Ireland D08 NHY1 Dublin, Ireland.
Current oncology (Toronto, Ont.)
|December 24, 2025
概括
75岁及以上患者的结肠直肠癌手术具有可接受的结果. 高查尔森并发症指数 (CCI) 评分预测并发症,而微创手术可能会改善结果.
科学领域:
- 老年人手术是一门老年人手术.
- 手术瘤学手术瘤学
- 研究成果 研究成果 研究成果
背景情况:
- 患有结直肠癌 (CRC) 的老年患者 (≥75岁) 在结局研究中代表性不足.
- 准确的风险分层对于这一群体的手术决策至关重要.
- 查尔森并发症指数 (CCI) 是评估并发症负担的关键工具.
研究的目的:
- 评估75岁及以上患者结直肠癌切除术的结果.
- 评估查尔森并发症指数 (CCI) 对这一群体不良结果的预测值.
- 确定手术方法对结果的影响.
主要方法:
- 对211名接受CRC切除的患者 (≥75岁) 的回顾性审查 (2019年1月至2024年9月).
- 主要结局:主要手术后并发症 (Clavien-Dindo等级≥3) 或30天死亡率的组合.
- 按CCI分层 (≥5与<5);分析包括千平方,费舍尔精确和曼-惠特尼U测试.
主要成果:
- 平均年龄为81岁;24.6%的CCI≥5.
- 患有CCI≥5的患者的重大并发症或30天死亡率明显更高 (29.4%对11.9%,p=0.04).
- 腹腔镜切除具有独立的保护性 (aOR 0.37,p=0.048);年龄≥85岁和紧急呈现并不是显著的预测因素.
结论:
- 75岁以上的患者的结肠直肠切除与可接受的发病率和低死亡率有关.
- CCI ≥5是老年CRC患者不良结果的显著预测指标.
- 微创手术可能为这个高风险群体带来优势.
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