尿道代谢变化和潜在的运动诱导的肌肉损伤生物标志物在经过训练的年轻男性在急性间歇性训练后的识别
Yang Cheng1,2, Yue Yi1, Xuefeng Shi3
1School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
急性间歇性划船训练 (AIRT) 在训练有素的男性中引起运动诱导肌肉损伤 (EIMD),改变尿路代谢物. 四种化合物显示为评估EIMD的非侵入性生物标志物具有前途.
科学领域:
- 运动生理学 运动生理学
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 急性间歇性划船训练 (AIRT) 可以诱导运动诱导的肌肉损伤 (EIMD).
- 了解对EIMD的代谢反应对于运动员的监测和恢复至关重要.
- 泌尿代谢学提供了一种非侵入性的方法来评估运动后的生理变化.
研究的目的:
- 在训练有素的年轻男性中研究AIRT后尿道代谢概况的变化.
- 为了确定潜在的尿路生物标志物,表明EIMD.
- 为了将尿路代谢物变化与肌肉损伤和免疫反应的生理标志物相关联.
主要方法:
- 22名训练有素的年轻男性接受了AIRT.
- 血液的生物化学指数,肌肉功能 (反运动跳跃) 和疼痛被评估以评估EIMD.
- 对AIRT后立即采集的尿样进行了非向的代谢分析.
- 统计分析发现了显著改变的代谢物和途径.
主要成果:
- AIRT显著增加了肌酸激酶,乳酸脱酶,肌酸激酶-MB和基酸脱酶.
- 显著的免疫反应和跳跃性能下降表明了EIMD.
- 在AIRT后,尿中代谢物的33个被上调,12个被下调.
- 关键的改变途径包括乙酸盐代谢,氨回收,尿素循环和谷甲代谢.
- 鉴定出2'-脱氧化丁,细胞因子,乙和胺为潜在的生物标志物.
结论:
- 在受过训练的男性中,AIRT有效诱导了EIMD,并显著改变了尿中代谢物概况.
- 对氧化应激,炎症和氨不平衡的代谢适应是这些尿路变化的基础.
- 已识别的尿路生物标志物为非侵入性,即时的EIMD评估提供了潜力.
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