对于脊椎椎间盘的氧气臭氧治疗程序有多安全? 治疗脊柱疾病的SIOOT协议
Marianno Franzini1, Salvatore Chirumbolo2, Francesco Vaiano1
1Italian Scientific Society of Oxygen-Ozone Therapy (SIOOT), 24020 Gorle, Italy.
Journal of imaging
|December 24, 2025
概括
肌内氧气臭氧 (O2-O3) 治疗对腰椎间盘的治疗有希望,为肌内注射提供了一个更安全的替代方案,具有可比的疼痛缓解和降低风险. 这种方法证明了生物可信性和作为一线治疗的潜力.
科学领域:
- 最少侵入性的脊柱手术
- 再生医学是一种再生医学.
- 疼痛管理 疼痛管理
背景情况:
- 氧气-臭氧 (O2-O3) 疗法用于腰椎椎间盘.
- 由于严重的并发症,内注射的疗效受到争议.
- 肌肉内O2-O3治疗是一种潜在的更安全的替代方案,具有可比的疼痛结果.
研究的目的:
- 评估肌肉内O2-O3治疗是否实现了与肌肉内核溶解相比的磁盘透和疗效.
- 评估肌肉内O2-O3治疗与肌肉内注射的安全性.
- 探索肌肉内O2-O3作为腰椎间盘的第一线治疗的潜力.
主要方法:
- 结合计算机断层扫描 (CT) 成像和生物物理扩散建模的混合方法研究.
- 七项符合条件的研究 (四项RCT,3项队列研究) 的元分析,涉及120名患者.
- 统计分析包括Hedges的g,赔率比率和伤害所需的数量 (NNH).
主要成果:
- CT成像证实了肌肉内O2-O3气体迁移到椎间盘.
- 肌肉内治疗显示显著减少疼痛 (黑奇斯的g = -1.55).
- 内治疗具有更高的疗效 (g = 2.87),但异质性和并发症率明显更高 (严重不良事件的NNH ≈ 1180).
结论:
- 肌肉内O2-O3疗法在腰椎间盘的治疗中是生物学上可信的,安全的和有效的.
- 它提供了一种更安全的替代方案,以减少手术风险.
- 支持采用作为一线的最少侵入性策略来管理腰椎间盘.
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