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3D打印的多功能多隔间聚合物基囊用于可调节和空间控制的药物释放

Antonio Minopoli^1,2, Giordano Perini^1,2, Davide Evangelista^1,2

¹Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.

Journal of functional biomaterials

|December 24, 2025

概括

这项研究介绍了一种3D打印方法,以创建先进的聚合物药物输送囊. 这些多隔间囊提供精确的,特定部位的药物释放,用于有针对性的肠道输送.

科学领域:

聚合物科学聚合物科学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

基于聚合物的系统对于开发先进的药物输送载体至关重要,因为它们具有可调节的特性.
设计复杂,灵敏的药物输送系统仍然是制药研究中的一个重大挑战.

研究的目的:

开发一种新的3D打印策略,用于制造多隔间聚合物囊.
在药物输送载体中实现精确的空间组织和结构复杂性.
为了实现可定制,本地化和特定站点的药物释放.

主要方法:

使用一步3D打印工艺制造多隔间囊.
在囊结构中集成多种聚合物.
在不同的聚合物区域中编程pH触发释放.

主要成果:

成功创建结构复杂的多间囊.
展示可定制的功能,包括区分和聚合物特定的响应能力.
实现局部化,pH触发的药物释放,用于肠道部分的特定部位的输送.

结论:

3D打印为生产多功能聚合物基载体提供了一个可扩展和适应的平台.
这种方法使得可微调的药物释放配置文件可用于受控的输送.
为聚合物支持的可控药物递送技术的新方向铺平了道路.

关键词:

通过3D打印打印3D打印.基于生物聚合物的囊.控制的药物释放控制的药物释放可食用的水凝.肠道涂层肠道涂层精油精油精油精油精油油微乳液微乳液是一种油.

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