细菌 velezensis A4 通过膜完整性破坏和真菌病原体细胞功能障碍对抗真菌病原体
Yu Xu1,2, Hongyan Zhu1, Wenxin Liu1,2
1School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China.
Journal of fungi (Basel, Switzerland)
|December 24, 2025
概括
细菌 velezensis A4 显示了对12种病原菌的广泛抗真菌活性. 它的无细胞超浮物破坏真菌膜并诱导细胞亡,为水果腐烂提供安全的生物控制.
科学领域:
- 农业科学 农业科学
- 微生物学 微生物学
- 生物技术是生物技术.
背景情况:
- 病原菌引起的收获后果腐烂导致了重大的经济和质量损失.
- 生物控制为控制水果中的真菌病提供了一个环保和安全的替代方案.
研究的目的:
- 为了研究Bacillus velezensis A4对各种病原菌的抗真菌功效.
- 为了阐明B. velezensis A4的无细胞超体 (CFS) 的潜在抗真菌机制.
主要方法:
- 对12种致病菌的对抗性测试.
- 分析无细胞超体 (CFS) 的组成部分.
- 对真菌对CFS的反应的转录组和代谢组分析.
- 研究与亡相关的途径.
主要成果:
- B. velezensis A4对12种经过测试的致病性真菌表现出显著的对抗作用.
- CFS诱导的形变形和破坏的真菌细胞膜的透性.
- 转录组和代谢组数据显示,CFS破坏了脂质平衡和细胞内组织.
- CFS的应用上调了膜氧化和caspase基因,启动了细胞亡.
结论:
- B. velezensis A4表现出广泛的抗真菌活性,使其成为一个有前途的生物控制剂.
- 抗真菌作用涉及破坏真菌细胞膜的完整性和诱导亡.
- 来自B. velezensis A4的CFS提供了一个可行的生物解决方案,用于收获后的水果保护.
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