双A (BPA) 修改癌症信号通路:一个被忽视的全球健康威胁
Minatullah Al-Ani1, Yassir Al-Ani2, Shahad Sabaawi Ibrahim1
1Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.
双甲 (BPA) 暴露与影响细胞信号通路的癌症发展有关. 不含BPA的替代品,如BPS和BPF,也可能造成健康风险,需要更安全的替代品和法规.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 癌症生物学 癌症生物学
背景情况:
- 双A (BPA) 是一种广泛存在于塑料中的工业化学物质.
- 人类对BPA的暴露正在增加,这引发了人们对其致癌潜力的担忧.
- BPA在组织中积累,尽管雌激素受体亲和力较低,但可以产生有害影响.
研究的目的:
- 审查目前关于双A在癌症发病和进展中的作用的证据.
- 专注于BPA对癌症信号通路的影响.
- 讨论暴露途径和BPA替代品的影响.
主要方法:
- 对 Bisphenol A 和癌症现有研究的文献综述.
- 分析BPA对调节生长,运动,入侵,生存和粘附的细胞通路的影响.
- 检查暴露途径,主要是从包装食品中的饮食摄入量.
主要成果:
- BPA充当雌激素连接体,激活雌激素受体通路.
- 它调节了参与癌症发展的关键信号通路.
- BPA从包装中的迁移随着温度的增加而增加,从而增加了暴露.
- 像BPS和BPF这样的BPA替代品可能会带来类似或更大的健康风险.
结论:
- BPA显著影响癌症信号通路,有助于癌症的开始和进展.
- 饮食暴露是一个主要问题,温度依赖的迁移加剧了这种情况.
- 由于潜在的健康风险,使用BPA替代品如BPS和BPF需要仔细评估.
- 对于安全的替代品,去除技术和监管措施,需要进一步的研究.
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