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东南亚的粘膜关联淋巴组织淋巴瘤:一项为期15年的回顾性多中心研究

Kannadit Prayongratana¹, Tanapun Thamgrang¹, Chonlada Laoruangroj¹

¹Division of Hematology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok 10400, Thailand.

Hematology reports

|December 24, 2025

概括

粘膜相关淋巴组织 (MALT) 淋巴瘤是边缘区域淋巴瘤 (MZL) 的常见亚型. 没有确定的风险因素的患者,如表现不佳或晚年,表现出明显改善的无进展生存率和整体生存率.

科学领域:

血液学血液学血液学
在瘤学瘤学.
流行病学流行病学

背景情况:

边缘区域淋巴瘤 (MZL) 是一种异质的非霍奇金淋巴瘤群.
粘膜相关淋巴组织 (MALT) 淋巴瘤是MZL最常见的亚型.
了解MALT淋巴瘤的流行病学和预后因素对于患者管理至关重要.

研究的目的:

为了调查MALT淋巴瘤的流行病学特征.
为了确定与MALT淋巴瘤相关的生存率和预后因素.
为确定MALT淋巴瘤患者的风险分层.

主要方法:

分析了泰国淋巴瘤研究小组 (TLSG) 登记册中的数据.
包括来自670名MALT淋巴瘤患者的人口统计,治疗和生存数据.
多变量分析确定了总生存 (OS) 和无进展生存 (PFS) 的预测因素.

主要成果:

在该队列中,MALT淋巴瘤占MZL病例的77.8%.
常见的主要部位包括眼部附录 (49.2%),胃 (12.9%) 和鼻腔区域 (12.5%).
ECOG表现状态>2,年龄>65,以及涉及>2个外节器官是显著的不良预后因素. 与高风险患者相比,没有风险因素的患者的5年PFS (83.3%) 和OS (97.8%) 显著改善.

结论:

在这个泰国队列中,MALT淋巴瘤是MZL的主要亚型.
一个简单的风险分类基于ECOG状态,年龄和外节干预可以预测结果.
风险分层管理可能会改善MALT淋巴瘤患者的治疗结果.

关键词:

马尔特淋巴瘤 (MALT) 是一种淋巴瘤.额外的边缘区域淋巴瘤边缘区域淋巴瘤边缘区域淋巴瘤粘膜相关的淋巴组织淋巴瘤.

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