生物标志物 生物标志物
Jessamine F Kuehn1, Qijun Zhang1, Margo B Heston2
1Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
肠道细菌代谢物短链脂肪酸 (SCFA),如和丁酸盐,在粉样蛋白阳性状态的个体中减少,这表明在阿尔茨海默病 (AD) 进展中可能发挥作用.
科学领域:
- 微生物组研究的研究.
- 神经退行性疾病生物标志物神经退行性疾病生物标志物
- 代谢学 代谢学 代谢学
背景情况:
- 短链脂肪酸 (SCFA) 是来自纤维发酵的肠道细菌代谢产物.
- 临床前研究表明,SCFA可以预防阿尔茨海默氏症 (AD) 病理.
- 对SCFA,肠道细菌和AD生物标志物的人类数据有限.
研究的目的:
- 调查肠道微生物SCFA生产和AD生物标志物在认知不受损的个体之间的关系.
- 确定SCFA水平或产生它们的细菌是否与临床前AD病理有关.
- 探索SCFA和AD进展之间的潜在因果关系.
主要方法:
- 分析了213名患有AD风险的认知正常参与者的便样本中的肠道转基因组和SCFA水平.
- 测序便DNA以组装元基因组组合基因组 (MAGs) 并识别功能基因.
- 用回归分析测量SCFA水平并将其与脑脊液 (CSF) 的AD生物标志物相关联.
主要成果:
- 减少MAG的丰富度编码酸盐和丁酸盐生产途径在粉素阳性参与者.
- 在女性和粉素阳性个体中观察到酸盐,酸盐和丁酸盐的便水平较低.
- 调解分析表明,丁酸盐在微生物途径和粉样状况之间的关联中可能发挥作用.
结论:
- 粉样蛋白阳性个体表现出肠道微生物和丁酸盐生产途径的减少.
- 这些在人类中的发现与临床前数据一致,表明SCFA可能会影响AD的进展.
- SCFA及其产生的细菌代表了AD预防或治疗的潜在目标.
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