怀孕和新生儿结局没有男性伴侣的妇女通过宫内授精接受生育护理:回顾性队列研究
Wendy Y Zhang1,2, Megan McCracken1, Amy Zhang3
1Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94087, USA.
Journal of personalized medicine
|December 24, 2025
概括
没有男性伴侣的女性接受子宫内授精 (IUI),与男性伴侣的女性相比,怀孕和活产率相似. 产科和新生儿结局在各组之间也相似,在生育治疗中表现出公平的结果.
科学领域:
- 生殖医学 生殖医学
- 产科和妇科 产科和妇科
- 不孕症治疗 不孕症治疗
背景情况:
- 宫内授精 (IUI) 是一种常见的生育治疗方法.
- 了解不同患者群体的结果对于公平护理至关重要.
- 之前的研究没有广泛比较没有男性伴侣的女性的IUI结果.
研究的目的:
- 为了比较没有男性伴侣的妇女与男性伴侣的妇女的子宫内授精 (IUI) 妊娠和新生儿结果.
- 评估临床怀孕,流产,活产,产科并发症和新生儿结局的发生率.
- 评估不同社会结构中IUI的有效性和安全性.
主要方法:
- 从2017年到2023年,对2414个IUI周期进行了回顾性队列研究.
- 包括没有男性伴侣的女性 (单身,女同性恋) 的149个周期和男性伴侣的女性的2265个周期.
- 主要结局:临床怀孕,流产,活产率. 二次结局:产科和新生儿并发症.
主要成果:
- 没有男性伴侣的女性年龄较大 (中位数为42岁与38岁),并且经常没有被诊断出不孕症的原因.
- 临床怀孕率 (11.4%对12.5%) 和活产率 (8.1%对8.2%) 在各组之间相似.
- 没有观察到流产,多胎妊娠,产科并发症或新生儿结局的显著差异,即使经过对混因素进行调整.
结论:
- 宫内授精 (IUI) 在没有男性伴侣的女性和男性伴侣的女性中产生了可比的怀孕和活产率.
- 用IUI治疗生育能力,在两个群体的产科和新生儿结局方面表现出相似的安全性.
- 这项研究支持IUI对不同伙伴关系状态的女性的有效性和安全性.
更多相关视频
06:49Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
Published on: April 7, 2023
2.1K
08:06Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
Published on: October 18, 2024
772
相关概念视频
Infertility in Males
507
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
507
Infertility in Females
3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.6K
In Vitro Fertilization
836
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
836
Fertilization
89.2K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
89.2K
Birth Control Methods
5.8K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.8K
